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MLLT11 gene

Known as: AF1Q, ALL1 fused gene from chromosome 1q, Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 11 Gene 
This gene is involved in mitochondrial functions.
National Institutes of Health

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MLLT11 wt Allele
Positive Regulation of ApoptosisProtein AF1qTranscriptional Activation

Papers overview

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2017
2017
Molecular characterization of KMT2A fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes
In pediatric acute leukemias, reciprocal chromosomal translocations frequently cause gene fusions involving the lysine (K… 
2014
2014
ИССЛЕДОВАНИЕ СТРУКТУРЫ ХИМЕРНЫХ ГЕНОВ С УЧАСТИЕМ ГЕНА MLL ПРИ ОСТРЫХ ЛЕЙКОЗАХ У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ
Р е з ю м е. Целью данной работы являлось описание механизмов образования химерных генов с вовлечением гена MLL… 
2013
2013
MLL genomic DNA Breakpoints In Infant Acute Leukemia
Background Infant acute leukemia is characterized by high incidence of MLL gene rearrangements. Purpose To evaluate the… 
Review
2012
Review
2012
Molecular Identification of a New Splicing Variant of the MLL-MLLT11 Fusion Transcript in an Adult with Acute Myeloid Leukemia and t(1;11)(q21;q23)
More than 70 different mixed lineage leukemia (MLL) rearrangements involving 11q23 have been molecularly characterized in acute… 
2011
2011
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML
MLLT11, an MLL fusion partner, is a poor prognostic biomarker for paediatric acute myeloid leukaemia (AML), adult normal… 
2011
2011
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
The mechanisms regulating the emergence of BM prothymocytes remain poorly characterized. Genome-wide transcriptome analyses… 
2010
2010
ETV6-ARNT fusion in a patient with childhood T lymphoblastic leukemia.
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