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MLLT11 gene

Known as: AF1Q, ALL1 fused gene from chromosome 1q, Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 11 Gene 
This gene is involved in mitochondrial functions.
National Institutes of Health

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MLLT11 wt Allele
Positive Regulation of ApoptosisProtein AF1qTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer
2018
2018
Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia
Tyrosine kinase inhibitor treatment of chronic myeloid leukemia (CML) has demonstrated beneficial effects. However, resistance to… 
2017
2017
AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling
The up-regulation of ALL1-fused gene from chromosome 1q (AF1q) is commonly seen in aggressive hematologic malignancies as well as… 
2017
2017
Involvement of AF1q/MLLT11 in the progression of ovarian cancer
The functional role of AF1q/MLLT11, an oncogenic factor involved in a translocation t(1;11)(q21;q23) responsible for acute… 
2016
2016
Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors
BackgroundWilms tumor (WT) has a not completely elucidated pathogenesis. DNA copy number alterations (CNAs) are common in cancer… 
2015
2015
Gene set enrichment and topological analyses based on interaction networks in pediatric acute lymphoblastic leukemia
Pediatric acute lymphoblastic leukemia (ALL) accounts for over one-quarter of all pediatric cancers. Interacting genes and… 
2014
2014
MLLT11/AF1q is differentially expressed in maturing neurons during development.
2011
2011
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML
MLLT11, an MLL fusion partner, is a poor prognostic biomarker for paediatric acute myeloid leukaemia (AML), adult normal… 
2011
2011
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
The mechanisms regulating the emergence of BM prothymocytes remain poorly characterized. Genome-wide transcriptome analyses… 
Highly Cited
2006
Highly Cited
2006
Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis.
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