Protein AF1q

Known as: AF1Q, MLLT11 
Protein AF1q (90 aa, ~10 kDa) is encoded by the human MLLT11 gene. This protein is involved in the regulation of mitochondrial homeostasis.
National Institutes of Health

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Genes, RegulatorMLLT11 geneMLLT11 wt AllelePositive Regulation of Apoptosis
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Papers overview

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2016
2016
MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling
Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for… (More)
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2015
2015
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis
AF1q is an MLL fusion partner that was identified from acute myeloid leukemia (AML) patients with t (1; 11) (q21; q23… (More)
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2014
2014
Degradation of AF1Q by chaperone-mediated autophagy.
AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid… (More)
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2014
2014
MLLT11/AF1q is differentially expressed in maturing neurons during development.
Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11 or ALL1 fused from chromosome 1q (MLLT11/AF1q) is a… (More)
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2011
2011
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
The mechanisms regulating the emergence of BM prothymocytes remain poorly characterized. Genome-wide transcriptome analyses… (More)
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2011
2011
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML.
MLLT11, an MLL fusion partner, is a poor prognostic biomarker for paediatric acute myeloid leukaemia (AML), adult normal… (More)
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2008
2008
Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway.
AF1q is an oncogenic factor involved in leukemia development, thyroid tumorigenesis, and breast cancer metastasis. In the present… (More)
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2008
2008
AF1q enhances doxorubicin induced apoptosis through mitochondrial apoptotic pathway.
2691 AF1q (ALL1-fused gene chromosome 1q) is an oncogenic factor involved in leukemia development, thyroid tumourigenesis and… (More)
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2007
2007
Identification of the functional role of AF1Q in the progression of breast cancer
A novel highly metastatic MDA-MB-231HM cells, derived from MDA-MB-231, was established in our institute. RT-PCR, real-time PCR… (More)
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1999
1999
MLL-AF1q fusion resulting from t(1;11) in acute leukemia
The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal… (More)
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