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Protein AF1q

Known as: AF1Q, MLLT11 
Protein AF1q (90 aa, ~10 kDa) is encoded by the human MLLT11 gene. This protein is involved in the regulation of mitochondrial homeostasis.
National Institutes of Health

Related topics

Related topics

6 relations
Genes, RegulatorMLLT11 geneMLLT11 wt AllelePositive Regulation of Apoptosis
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer
Although several previous studies have reported the implication of various microRNAs (miRNAs) in regulation of human bladder… Expand
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2016
2016
MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling
Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for… Expand
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2014
2014
Degradation of AF1Q by chaperone-mediated autophagy.
AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid… Expand
2013
2013
The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells.
Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and… Expand
2011
2011
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML
MLLT11, an MLL fusion partner, is a poor prognostic biomarker for paediatric acute myeloid leukaemia (AML), adult normal… Expand
2011
2011
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
The mechanisms regulating the emergence of BM prothymocytes remain poorly characterized. Genome-wide transcriptome analyses… Expand
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2008
2008
Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway
AF1q is an oncogenic factor involved in leukemia development, thyroid tumorigenesis, and breast cancer metastasis. In the present… Expand
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2007
2007
Identification of the functional role of AF1Q in the progression of breast cancer
A novel highly metastatic MDA-MB-231HM cells, derived from MDA-MB-231, was established in our institute. RT-PCR, real-time PCR… Expand
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Highly Cited
2006
Highly Cited
2006
Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes
Introduction: Testicular germ cell tumors of adolescent and young adult men (TGCTs) generally have near triploid and complex… Expand
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1999
1999
MLL-AF1q fusion resulting from t(1;11) in acute leukemia
The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal… Expand
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