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MLLT10 gene

Known as: MLLT10, MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 10, ALL1-FUSED GENE FROM CHROMOSOME 10 
This gene may be involved in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

6 relations
Homo sapiensMLL-AF10 Fusion Protein ExpressionProtein AF-10Transcriptional Regulation

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MLLT10 wt Allele

Papers overview

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2019
2019
A higher-order configuration of the heterodimeric DOT1L–AF10 coiled-coil domains potentiates their leukemogenenic activity
Significance The leukemogenic function of the MLL1–AF10 fusion protein is caused by aberrant recruitment of histone… 
2010
2010
Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.
The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients. Expression of a CALM-AF10… 
2005
2005
Cryptic MLL-AF10 fusion caused by insertion of duplicated 5' part of MLL into 10p12 in acute leukemia: a case report.
Highly Cited
2002
Highly Cited
2002
The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.
The AF10 gene encodes a putative transcription factor containing an N-terminal LAP/PHD zinc finger motif, a functional nuclear… 
Highly Cited
2000
Highly Cited
2000
Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia
The t(10;11)(p12-p13;q14-q21) observed in a subset of patients with either acute lymphoblastic leukemia or acute myeloid leukemia… 
1999
1999
The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene
The MLL gene is reciprocally translocated with one of a number of different partner genes in a proportion of human acute… 
1998
1998
Expression pattern and cellular distribution of the murine homologue of AF10.
1998
1998
Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13–14;q14–q21) suggests a potential role for truncated AF10 polypeptides
The t(10;11)(p13;q14–21) is a non-random translocation that occurs primarily in T cell acute lymphoblastic leukemias (T-ALL), but… 
1996
1996
AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).
Invins(10;11)(p12;q23q12) is one of the rare but recurring chromosome rearrangements seen in acute monoblastic leukemia. We… 
1995
1995
A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7)
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