MLLT10 gene

Known as: MLLT10, MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 10, ALL1-FUSED GENE FROM CHROMOSOME 10 
This gene may be involved in transcriptional regulation.
National Institutes of Health

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Homo sapiensMLL-AF10 Fusion Protein ExpressionProtein AF-10Transcriptional Regulation
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MLLT10 wt Allele

Papers overview

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2014
2014
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79… (More)
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2013
2013
New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.
The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent… (More)
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2012
2012
EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.
results from the MOLI-SANI project. Haematologica, 96, 1180–1188. Siervo, M., Ruggiero, D., Sorice, R., Nutile, T., Aversano, M… (More)
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2011
2011
Common variation at 10p12.31 near MLLT10 influences meningioma risk
To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases… (More)
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2006
2006
The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10
The Clathrin Assembly Lymphoid Myeloid leukemia gene (CALM or PICALM) was first identified as the fusion partner of AF10 in the t… (More)
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2006
2006
HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation
Recognized T-cell acute lymphoblastic leukemias (T-ALLs) oncogenic pathways include transcriptional deregulation of oncogenes by… (More)
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2004
2004
Purification and characterization of inulinase from Aspergillus niger AF10 expressed in Pichia pastoris.
The inuA1 gene encoding an exoinulinase from Aspergillus niger AF10 was expressed in Pichia pastoris, and the recombinant enzyme… (More)
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2003
2003
The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.
In a screen for Drosophila genes that interfere with transcriptional repression mediated by the Polycomb group of genes, we… (More)
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2000
2000
Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients
The recurring translocation t(10;11)(p13;q14) which is found in acute myeloid leukemia (AML) and in acute lymphoblastic leukemia… (More)
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1996
1996
AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).
Invins(10;11)(p12;q23q12) is one of the rare but recurring chromosome rearrangements seen in acute monoblastic leukemia. We… (More)
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