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MK-422 (enalaprilat) (0.0005-0.5%) significantly reduced intraocular pressure (IOP) in African Green monkeys. Studies utilizing… Expand Nineteen mongrel dogs had 30 minutes of thoracic aortic occlusion to determine the effects that blockade of the renin-angiotensin… Expand The acute hemodynamic and hormonal effects of the oral angiotensin-converting enzyme (ACE) inhibitor lisinopril (MK-521) were… Expand The spontaneously hypertensive rat (SHR) has many characteristics indicative of an overactive brain-angiotensin system. Since… Expand The in vitro conversion of enalapril (MK421) to enalaprilic acid (MK422) in human autopsy tissues was examined. MK422 was… Expand Endopeptidase-24.11 (EC 220.127.116.11), purified to homogeneity from pig kidney, was shown to hydrolyse a wide range of neuropeptides… Expand The hydrolysis of substance P is catalyzed by purified rabbit lung angiotensin-converting enzyme (peptidyldipeptide hydrolase, EC… Expand In hypertensive patients the time courses for the rise in serum MK-422 level, and fall in both angiotensin converting enzyme (ACE… Expand Animal studies (particularly in dogs) on enalapril maleate have served to predict the patterns of absorption and elimination… Expand 1 The disposition of two angiotensin converting-enzyme inhibitor drugs was studied in normal volunteers. One drug was enalapril… Expand