Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung.
- D. W. Cushman, H. Cheung
- Biology, ChemistryBiochemical Pharmacology
- 1 July 1971
Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.
- D. W. Cushman, H. Cheung, E. F. Sabo, M. Ondetti
- BiologyBiochemistry
- 13 December 1977
Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents.
- M. Ondetti, B. Rubin, D. W. Cushman
- Chemistry, BiologyScience
- 22 April 1977
A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled a new class of potent and specific inhibitors, carboxyalkanoyl and mercaptoalkanoysl derivatives of proline, to be designed.
Enzymes of the renin-angiotensin system and their inhibitors.
- M. Ondetti, D. W. Cushman
- Chemistry, MedicineAnnual Review of Biochemistry
- 1982
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.
- H. Cheung, F. Wang, M. Ondetti, E. F. Sabo, D. W. Cushman
- Biology, ChemistryJournal of Biological Chemistry
- 25 January 1980
Results suggest that selective binding of the COOH-terminal dipeptide residue is an impor tan t dete rminant of both the substrate specificity of angiotensin-converting enzyme and the degree of rate stimulation by chloride ion, and that the nature of this selective binding can be further clarified by studying competitive inhibition of dpeptides of vary ing structure.
Concentrations of angiotensin-converting enzyme in tissues of the rat.
- D. W. Cushman, H. Cheung
- Biology, ChemistryBiochimica et Biophysica Acta
- 20 October 1971
Design of angiotensin converting enzyme inhibitors
- D. W. Cushman, M. Ondetti
- Medicine, BiologyNature Network Boston
- 1 October 1999
Specific inhibitors of angiotensin-converting enzyme, known to the lay public as ACE inhibitors, have now been embraced by the medical community as first-line therapy for hypertensive disease and…
History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme
- D. W. Cushman, M. Ondetti
- BiologyHYPERTENSION
- 1 April 1991
In describing the development of captopril and related antihypertensive drugs, we hope to resurrect a more specific meaning for the term "drug design," namely, the logical process whereby molecules…
Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca.
- H. Cheung, D. W. Cushman
- Biology, ChemistryBiochimica et Biophysica Acta
- 15 February 1973
INHIBITORS OF ANGIOTENSIN I CONVERTING ENZYME
- D. W. Cushman, M. Ondetti
- MedicineProgress in Medicinal Chemistry
- 1980
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