MK 2206

Known as: Akt inhibitor MK2206, MK-2206, MK2206 
An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
02040608020092017

Papers overview

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2013
2013
Cholangiocarcinoma (CCA) is a rare, but devastating disease arising from the epithelium of intrahepatic and extrahepatic bile… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE We tested the hypothesis that allosteric Akt inhibitor MK-2206 inhibits tumor growth, and that PTEN/PIK3CA mutations… (More)
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2012
2012
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder arising from T-cell progenitors. T-ALL accounts… (More)
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2012
2012
Gefitinib, a small molecule inhibitor of the epidermal growth factor receptor tyrosine kinase, has been shown to induce autophagy… (More)
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2012
2012
PURPOSE Activation of Akt is a marker of decreased event-free or overall survival in neuroblastoma patients. MK-2206, a novel… (More)
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2012
2012
BACKGROUND MK-2206 is a small molecule allosteric inhibitor of Akt/PKB that is undergoing clinical trials for treatment of cancer… (More)
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2012
2012
PURPOSE The mTOR pathway is constitutively activated in diffuse large B-cell lymphoma (DLBCL). mTOR inhibitors have activity in… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE AKT signaling is frequently deregulated in human cancers. MK-2206 is a potent, oral allosteric inhibitor of all AKT… (More)
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Highly Cited
2010
Highly Cited
2010
The serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in… (More)
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Highly Cited
2010
Highly Cited
2010
AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in… (More)
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