• Publications
  • Influence
Prognostic value of PD-L1 and PD-1 expression in pulmonary neuroendocrine tumors
TLDR
It is suggested that PD-L1 and PD-1 can be useful prognostic biomarkers for survival and can pave the way toward new immunotherapy regimens against PNETs through targeting the PD- L1/PD-1 pathway. Expand
PD-L1 and PD-1 expression correlate with prognosis in extrahepatic cholangiocarcinoma
TLDR
Preliminary results suggested that PD-L1 or PD-1 immunodetection may be a valuable prognostic marker for ECC patients, and thatPD-L 1 immunodetic may be used as an independent factor to evaluate the prognosis of patients with ECC. Expand
Potential biomarkers for anti-EGFR therapy in metastatic colorectal cancer
TLDR
Applications of multiple biomarkers are more effective than the use of a single biomarker in selecting patients who might benefit from cetuximab- or panitumumab-based treatments, and many microRNAs and additional molecular biomarker are promising in predicting the efficacy of anti-EGFR therapy. Expand
Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer
TLDR
It is demonstrated that the combined detection of the protein expression of Nm23-H1 and p53 was associated with the long term survival rates of patients with stage II and III CRC; and this may offer potential for use as a predictor of survival rates in patients with CRC. Expand
Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study
TLDR
Risks of SPMs increases in CRC survivors, especially in the first 5 years after prior diagnosis, and intensive surveillance should be advocated among young patients, with specific attention to the small intestine, colorectum, renal pelvis, and ureter. Expand
Prognostic value of PD-L 1 expression in non-small cell lung cancer : a meta-analysis
Purpose: We conducted a meta-analysis to systematically assess the prognostic and clinicopathological value of programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer (NSCLC).Expand
MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer
TLDR
Findings indicate MTA1 promotes NSCLC cell EMT and metastasis via AKT/GSK3β/β-catenin signaling, which suggests MTA1 may be an effective anti-NSCLC therapeutic target. Expand
A Sensitive and Selective Method for Determination of Aesculin in Cortex Fraxini by Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry and Application in Pharmacokinetic Study
  • Y. Li, Hui Guo, +4 authors E. Li
  • Chemistry, Medicine
  • Journal of analytical methods in chemistry
  • 25 September 2013
TLDR
Pharmacokinetic study showed that aesculin was confirmed to be a one-compartment open model and the method is believed to have good linear range, high sensitivity and recoveries, and superior analytical efficiency. Expand
α‐Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades
  • Yu Shi, Y. Fan, +7 authors D. Dong
  • Chemistry, Medicine
  • Journal of cellular and molecular medicine
  • 25 November 2019
TLDR
It is found that α‐Mangostin, as a dietary xanthone, repressed the proliferation and clone formation ability, induced cell cycle arrest and the apoptosis, and suppressed de novo lipogenesis of gallbladder cancer cells. Expand
A Comprehensive Meta-Analysis of Association between EGFR Mutation Status and Brain Metastases in NSCLC
TLDR
This meta-analysis suggests that EGFR mutation can be a risk factor for BM in NSCLC, and a total of 26 studies were identified finally, indicating that EG FR mutation had a positive association with BM ofNSCLC. Expand
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