MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer

@article{Ma2017MTA1PE,
  title={MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer},
  author={Ke Ma and Yangwei Fan and Xuyuan Dong and Danfeng Dong and Yuyan Guo and Xin Wei and Jing Ning and Qianqian Geng and Chuying Wang and Yuan Hu and Mengya Li and Wenxia Niu and Enxiao Li and Yinying Wu},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={38825 - 38840}
}
The present study assessed the role of metastasis-associated protein 1 (MTA1) in epithelial to mesenchymal transition (EMT) and metastasis in non-small-cell lung cancer (NSCLC) cells using a normal lung epithelium cell line, three NSCLC cell lines, a mouse NSCLC model, and 56 clinical NSCLC samples. We observed that MTA1 overexpression decreased cellular adhesion, promoted migration and invasion, and changed cytoskeletal polarity. MTA1 knockdown had the opposite effects. MTA1 overexpression… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
MTA-1 expression is associated with metastasis and epithelial to mesenchymal transition in colorectal cancer cells
TLDR
MTA1 is highly expressed in higher grade tumors and is important in the orchestration of various phenotypic changes in CRC, most likely by inducing EMT, which corroborates its role as a master regulator in tumorigenesis. Expand
Akt Mediates Metastasis-Associated Gene 1 (MTA1) Regulating the Expression of E-cadherin and Promoting the Invasiveness of Prostate Cancer Cells
TLDR
The silencing of MTA1 by siRNA treatment results in the upregulation of E-cadherin expression by the phosphorylation of AKT (p-AKT) and decreases the invasiveness of prostate cancer cells. Expand
MTA1 promotes metastasis of MPM via suppression of E-cadherin
TLDR
MTA1 plays an important role in Epithelial-to-mesenchymal transition (EMT) to promote metastasis via suppressing E-cadherin expression, resulting in a poor prognosis in MPM. Expand
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic.
TLDR
This review summarizes the main EMT characteristics and proposes methodologies for better analysis in vitro and cites the recent literature concerning the mechanisms of drug resistance related to EMT in the context of anti-tumour therapies and proposes related new targets for therapy. Expand
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
TLDR
Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up- regulation of the mesenchymal marker vimentin. Expand
Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways
TLDR
The role of PI3K/AKT pathways in EMT during development and cancer with a focus on E-cadherin regulation is discussed, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control. Expand
Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial–mesenchymaltransition
TLDR
The data suggest that EIF5A2 plays an important oncogenic role in CRC aggressiveness by the upregulation of MTA1 to induce EMT, and EIF 5A2 could be employed as a novel prognostic marker and/or effective therapeutic target for CRC. Expand
Epithelial-to-Mesenchymal Transition in the Development and Progression of Adenocarcinoma and Squamous Cell Carcinoma of the Lung
TLDR
The findings suggest that epithelial-to-mesenchymal transition is a potential target for lung cancer chemoprevention and therapy. Expand
Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways*
TLDR
Molecular evidence is provided that leptin induces breast cancer cells to undergo a transition from epithelial to spindle-like mesenchymal morphology and identifies an important modifier of Wnt1 signaling, MTA1, which is integral to leptin-mediated regulation of the Wnt/β-catenin pathway. Expand
TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells
TLDR
It is suggested that TGF-β1 regulates the components of EMT via stimulating the expression of MTA1, which in turn, induces FosB to repress E-cadherin expression and thus, revealed an inherent function of MTA 1 as a target and effector of TGF -β1 signaling in epithelial cells. Expand
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4
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