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MK 0462

Known as: MK 462, MK-0462, MK-462 
National Institutes of Health

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Broader (1)

rizatriptan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Rizatriptan: a new 5-HT1B/1D receptor agonist for the treatment of migraine.
Rizatriptan (MAXALT MK-0462) is a new 5-HT(1B/1D) receptor agonist for the acute treatment of migraine. The marketed 10 mg and 5… 
Review
1997
Review
1997
Acute migraine therapy: the newer drugs
In 1996, our knowledge of acute antimigraine therapy expanded in three major areas. First, large surveys have confirmed the… 
1996
1996
Pilot Study of MK-462 in Migraine
MK-462 is a potent, selective 5HT1D receptor agonist which may be useful in treating acute migraine. We conducted a double-blind… 
1996
1996
Pharmacokinetics and food interaction of MK-462 in healthy males.
A study was conducted to assess the safety, tolerability, and pharmacokinetics of single intravenous (IV) doses of 5-90… 
1996
1996
The use of stable isotope labeling and liquid chromatography/tandem mass spectrometry techniques to study the pharmacokinetics and bioavailability of the antimigraine drug, MK-0462 (rizatriptan) in…
MK-0462 (rizatriptan) is a 5HT1D agonist being developed for the treatment of migraine. The assay for this substance in plasma… 
1996
1996
Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors
Abstract5-Hydroxytryptamine (serotonin, 5-HT), essentially known as a neurotransmitter and vasoactive agent, also functions as a… 
1996
1996
MK‐462 in migraine: A pilot study
Clinical Pharmacology & Therapeutics (1996) 59, 196–196; doi: 10.1038/sj.clpt.1996.283 
1996
1996
Monthly Update: Central & Peripheral Nervous Systems: Pharmacology of antimigraine 5-HT1D receptor agonists
The 5-HT 1D receptor agonist sumatriptan is undoubtedly a significant advance in the management of migraine and cluster attacks… 
1995
1995
A comparison of the contractile effects of 5-hydroxytryptamine, sumatriptan and MK-462 on human coronary artery in vitro.
1. MK-462 (N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H- indol-3-yl]ethylamine) is a novel selective 5-HT1D-receptor agonist… 
Review
1995
Review
1995
Acute treatment of migraine attacks.
Migraine is a chronic neurological disorder, characterized by attacks of severe, usually unilateral and throbbing headache… 
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