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MK 0431

Known as: 0431, MK, MK-0431, MK0431 
 
National Institutes of Health

Papers overview

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2010
2010
OBJECTIVE Treatment of NOD mice with the dipeptidyl peptidase-IV (DPP-IV) inhibitor sitagliptin preserved islet transplants… Expand
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The endopeptidase dipeptidyl peptidase-IV (DPP-IV) has been shown to NH2-terminally truncate incretin hormones, glucose… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE Dipeptidyl peptidase-IV (DPP-IV) inhibitors have been introduced as therapeutics for type 2 diabetes. They partially… Expand
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2007
2007
Sitagliptin (MK-0431) is an orally active, potent, and selective dipeptidyl peptidase-4 inhibitor used for the treatment of… Expand
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2007
2007
The pharmacokinetics, metabolism, and excretion of sitagliptin [MK-0431; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4… Expand
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2007
2007
The metabolism and excretion of [C]sitagliptin, an orally active, potent and selective dipeptidyl peptidase 4 inhibitor, were… Expand
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Highly Cited
2006
Highly Cited
2006
Aims/hypothesisThe aim of this study was to assess the efficacy and safety of sitagliptin (MK-0431) as monotherapy in patients… Expand
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Highly Cited
2006
Highly Cited
2006
Sitagliptin (MK-0431) is an oral, potent, and selective dipeptidyl peptidase-IV (DPP-4) inhibitor developed for the treatment of… Expand
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2006
2006
A robust and sensitive method using high turbulence liquid chromatography (HTLC) online extraction with tandem mass spectrometry… Expand
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Highly Cited
2005
Highly Cited
2005
A novel series of beta-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated… Expand
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