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sitagliptin

Known as: Sitagliptin [Chemical/Ingredient], 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine, Sitagliptinum 
An orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity. Sitagliptin may… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4… Expand
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Highly Cited
2015
Highly Cited
2015
n engl j med nejm.org 1 From the Duke Clinical Research Institute, Duke University School of Medicine, Durham (J.B.G., J.G., M.J… Expand
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Highly Cited
2010
Highly Cited
2010
Biocatalytic Boost Enzymes tend to direct reactions toward specific products much more selectively than synthetic catalysts… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Agonists of the glucagon-like peptide-1 (GLP-1) receptor provide pharmacological levels of GLP-1 activity, whereas… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Most patients with type 2 diabetes begin pharmacotherapy with metformin, but eventually need additional treatment. We… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Cases of acute pancreatitis have been reported in association with exenatide, sitagliptin, and type 2 diabetes without… Expand
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Highly Cited
2007
Highly Cited
2007
Aim:  To assess the efficacy and safety of a 24‐week treatment with sitagliptin, a highly selective once‐daily oral dipeptidyl… Expand
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Highly Cited
2006
Highly Cited
2006
Aims/hypothesisThe aim of this study was to assess the efficacy and safety of sitagliptin (MK-0431) as monotherapy in patients… Expand
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Review
2006
Review
2006
Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and suppresses glucagon secretion… Expand
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