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MIXED-LINEAGE KINASE 4

Known as: KIAA1804, MLK4 
National Institutes of Health

Papers overview

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2019
2019
Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
2019
2019
Clinical Evidence on the Interaction Between MLK4, KRAS and Microsatellite Instability to Determine the Prognosis of Early-Stage Colorectal Carcinoma.
BACKGROUND/AIMS MLK4 (KIAA1804) is the second most frequently mutated kinase in microsatellite stable (MSS) colorectal carcinomas… 
2018
2018
Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations
The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that… 
2018
2018
Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
Mixed-lineage kinase 3 (MLK3; also known as MAP3K11) is a Ser/Thr protein kinase widely expressed in normal and cancerous tissues… 
2018
2018
Identifying fenofibrate responsive CpG sites
As part of GAW20, we analyzed the familiality and variability of methylation to identify cytosine-phosphate-guanine (CpG) sites… 
Highly Cited
2014
Highly Cited
2014
DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes.
AIM The onset and progression of colorectal cancer (CRC) involves a cascade of genetic and/or epigenetic events. The aim of the… 
2012
2012
MLK4β functions as a negative regulator of MAPK signaling and cell invasion
Mixed lineage kinase (MLK) 4, or MLK4, is a member of the MLK family of mitogen-activated protein kinase kinase kinases (MAP3Ks… 
2011
2011
Cloning and Initial Functional Characterization of Mlk4α and Mlk4β
We have cloned a novel human mixed-lineage kinase gene, MLK4. Two alternatively spliced forms, MLK4α (580 aa) and MLK4β (1036 aa… 
2011
2011
MLK4 has negative effect on TLR4 signaling
The stimulation of Toll-like receptors (TLRs) on macrophages triggers production of proinflammatory cytokines such as tumor… 
Highly Cited
2008
Highly Cited
2008
Genomic profiling of 766 cancer‐related genes in archived esophageal normal and carcinoma tissues
We employed the BeadArray™ technology to perform a genetic analysis in 33 formalin‐fixed, paraffin‐embedded (FFPE) human… 
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