Skip to search formSkip to main contentSkip to account menu

MERTK protein, human

Known as: proto-oncogene protein c-mer, human, Receptor Tyrosine Kinase MerTK, c-mer proto-oncogene protein, human 
Tyrosine-protein kinase Mer (999 aa, ~110 kDa) is encoded by the human MERTK gene. This protein is involved in ligand-dependent signaling.
National Institutes of Health

Related topics

Related topics

24 relations
Cell Differentiation processCell ProliferationEnzyme GeneImmunoglobulin C2-set Domain

Broader (3)

Protein Tyrosine KinaseProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation
Apoptotic cells expose phosphatidylserine (PtdSer) on their surface, leading to efferocytosis, i.e. their engulfment by resident… 
2018
2018
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
MERTK is ectopically expressed and promotes survival in acute lymphoblastic leukemia (ALL) cells and is thus a potential… 
Highly Cited
2016
Highly Cited
2016
MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease.
Highly Cited
2014
Highly Cited
2014
MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands.
Definitive erythropoiesis takes place at erythroblastic islands, where erythroblasts proliferate and differentiate in association… 
Highly Cited
2008
Highly Cited
2008
The scavenger receptor SR‐A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages
Apoptotic cells (AC) must be cleared by macrophages (Mø) to resolve inflammation effectively. Mertk and scavenger receptor A (SR… 
Highly Cited
2007
Highly Cited
2007
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.
Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established… 
Highly Cited
2007
Highly Cited
2007
A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective…
Objectives Lithium is the most widely prescribed and effective mood-stabilizing drug used for the treatment of bipolar affective… 
Highly Cited
2005
Highly Cited
2005
Charge transport properties of tris(8-hydroxyquinolinato)aluminum(III): why it is an electron transporter.
The charge transport properties of mer-tris(8-hydroxyquinolinato)aluminum(III) (mer-Alq), which is the most widely used electron… 
Highly Cited
2004
Highly Cited
2004
MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells.
PURPOSE Mutations in the MERTK gene are responsible for retinal degeneration in the Royal College of Surgeons (RCS) rat and are a… 
Highly Cited
2004
Highly Cited
2004
The receptor tyrosine kinase MerTK activates phospholipase C γ2 during recognition of apoptotic thymocytes by murine macrophages
Apoptotic leukocytes must be cleared efficiently by macrophages (Mø). Apoptotic cell phagocytosis by Mø requires the receptor… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)