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MEN 16132

Known as: MEN-16132, MEN16132 
 
National Institutes of Health

Papers overview

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2016
2016
TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies
Background/Aims: The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the… Expand
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2013
2013
Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant.
OBJECTIVE The aim of this study was to determine in intact and inflamed knee joints of the rat, the effect of the bradykinin (BK… Expand
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2011
2011
Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B₂ receptor.
BACKGROUND AND PURPOSE Icatibant is a well-known kinin B₂ receptor antagonist currently used for angiooedema attacks. MEN16132 is… Expand
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2011
2011
Bradykinin and B₂ receptor antagonism in rat and human articular chondrocytes.
BACKGROUND AND PURPOSE In osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage… Expand
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2010
2010
Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats.
BACKGROUND AND PURPOSE Bradykinin, through its B(2) receptor, is involved in inflammatory processes related to arthropathies. In… Expand
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2010
2010
Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2
Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme… Expand
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2009
2009
Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.
BACKGROUND AND PURPOSE Bradykinin (BK) and B2 receptors have been implicated in the pathophysiology of osteoarthritis (OA), and… Expand
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2009
2009
Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.
The pharmacological profile of the bradykinin B(2) receptor antagonist MEN16132 at the rat B(2) receptor has been investigated… Expand
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2008
2008
MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways.
Kinins have been suggested to be involved in human airway diseases such as asthma and rhinitis. MEN16132 is a non-peptide kinin B… Expand
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2005
2005
MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.
The pharmacological characterization of the novel nonpeptide antagonist for the B2 receptor, namely MEN16132 (4-(S)-Amino-5-(4-{4… Expand
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