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MEN 16132

Known as: MEN-16132, MEN16132 
National Institutes of Health

Papers overview

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2012
2012
Fasitibant chloride, a kinin B2 receptor antagonist, and dexamethasone interact to inhibit carrageenan‐induced inflammatory arthritis in rats
BACKGROUND AND PURPOSE Bradykinin, through the kinin B2 receptor, is involved in inflammatory processes related to arthropathies… 
2011
2011
Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B2 receptor
BACKGROUND AND PURPOSE Icatibant is a well‐known kinin B2 receptor antagonist currently used for angiooedema attacks. MEN16132 is… 
2010
2010
Bradykinin-Induced Lung Inflammation and Bronchoconstriction: Role in Parainfluenze-3 Virus-Induced Inflammation and Airway Hyperreactivity
Inhaled bradykinin causes bronchoconstriction in asthmatic subjects but not nonasthmatics. To date, animal studies with inhaled… 
2010
2010
Anti‐inflammatory synergy of MEN16132, a kinin B2 receptor antagonist, and dexamethasone in carrageenan‐induced knee joint arthritis in rats
BACKGROUND AND PURPOSE Bradykinin, through its B2 receptor, is involved in inflammatory processes related to arthropathies. In… 
2009
2009
Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts
Background and purpose:  Bradykinin (BK) and B2 receptors have been implicated in the pathophysiology of osteoarthritis (OA), and… 
2009
2009
Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.
2008
2008
MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways.
2007
2007
Comparative antagonist pharmacology at the native mouse bradykinin B2 receptor: radioligand binding and smooth muscle contractility studies
The aim was to characterize the recently discovered non‐peptide antagonist MEN16132 at the mouse B2 receptor, relative to other… 
2007
2007
Characterization of kinin receptors in human cultured detrusor smooth muscle cells
Kinins have an important role in inflammatory cystitis and in animal pathophysiological models, by acting on epithelium… 
2005
2005
MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.
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