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MEN 16132

Known as: MEN-16132, MEN16132 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2016
012320052016

Papers overview

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2013
2013
Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant.
OBJECTIVE The aim of this study was to determine in intact and inflamed knee joints of the rat, the effect of the bradykinin (BK… (More)
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2012
2012
Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist.
BACKGROUND AND PURPOSE A (3) H-labelled derivative of the novel small-molecule bradykinin (BK) B(2) receptor antagonist JSM10292… (More)
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2011
2011
Bradykinin and Bâ‚‚ receptor antagonism in rat and human articular chondrocytes.
BACKGROUND AND PURPOSE In osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage… (More)
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2010
2010
Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats.
BACKGROUND AND PURPOSE Bradykinin, through its B(2) receptor, is involved in inflammatory processes related to arthropathies. In… (More)
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2010
2010
Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2
Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme… (More)
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2009
2009
Effect of Intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium…
The present study was designed to investigate the role of bradykinin (BK) in the knee joint osteoarthritis induced by intra… (More)
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2009
2009
Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.
BACKGROUND AND PURPOSE Bradykinin (BK) and B2 receptors have been implicated in the pathophysiology of osteoarthritis (OA), and… (More)
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2007
2007
Comparative antagonist pharmacology at the native mouse bradykinin B2 receptor: radioligand binding and smooth muscle contractility studies.
BACKGROUND AND PURPOSE The aim was to characterize the recently discovered non-peptide antagonist MEN16132 at the mouse B2… (More)
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2005
2005
MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.
The pharmacological characterization of the novel nonpeptide antagonist for the B2 receptor, namely MEN16132 (4-(S)-Amino-5-(4-{4… (More)
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2005
2005
MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized…
We have tested the activity of 4-(S)-amino-5-(4-[4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido… (More)
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