• Publications
  • Influence
Myogenic and neurogenic factors in the control of pyeloureteral motility and ureteral peristalsis.
The main, and possibly only, function of the pyeloureteral complex is to ensure the unidirectional transport of urine from the kidney to the urinary bladder. An extremely efficient set of mechanismsExpand
The nonstop transvesical cystometrogram in urethane-anesthetized rats: a simple procedure for quantitative studies on the various phases of urinary bladder voiding cycle.
A new cystometric procedure that involves a nonstop transvesical infusion of saline in urethane-anesthetized rats permits the obtainment of a series of repetitive voiding cycles in both male and female rats. Expand
Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.
Intravenous administration of the selective 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-N-propylaminotetralin (8-OH-DPAT) and of a low doses of buspirone elicited the supraspinalExpand
Tachykinins and calcitonin gene-related peptide as co-transmitters in local motor responses produced by sensory nerve activation in the guinea-pig isolated renal pelvis
These experiments indicate that peptide release from peripheral endings of capsaicin-sensitive primary afferents represents the major type of nerve-mediated response affecting motility of the guinea-pig isolated renal pelvis. Expand
Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats.
The mechanism(s) involved in determining the voiding cycle of the rat urinary bladder have been investigated in urethan-anesthetized animals and the reflex (hexamethonium sensitive) mechanism responsible for the generation of IPHFO is more developed in male than female rats. Expand
Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents.
It is concluded that CYP-induced cystitis is not accompanied by a toxic effect on bladder nerves and that the decrease in bladder capacity is entirely mediated through stimulation of capsaicin-sensitive afferent fibres, presumably linked to the formation of the irritant metabolite of CYP, acrolein. Expand
Hydrogen sulfide (H2S) stimulates capsaicin‐sensitive primary afferent neurons in the rat urinary bladder
Results provide pharmacological evidence that H2S stimulates capsaicin‐sensitive primary afferent nerve terminals, from which tachykinins are released to produce the observed contraction by activating NK1 and NK2 receptors. Expand
Pharmacology of transmission to gastrointestinal muscle.
Recent evidence obtained using receptor knockout mice have confirmed the involvement of the above-mentioned excitatory transmitters but have revealed an unexpected complexity in the nitrergic transmission, where the effects of NO are manifested only in the presence of carbon monoxide. Expand
Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans.
Observations provide the first indication that capsaicin-sensitive structures (nerves?) may be present in the human urinary bladder as they have been shown to occur in various other species. Expand
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta
To the knowledge, urantide is the most potent UT receptor antagonist so far described, and might represent a useful tool for exploring the (patho)physiological role of hU‐II in the mammalian cardiovascular system. Expand