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Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.
The findings indicate that nociceptin exerts a pronounced depressant effect on cardiovascular function which is produced indirectly through a concomitant inhibition and activation, respectively, of the sympathetic and parasympathetic outflows to the cardiovascular system. Expand
Peripheral actions of tachykinins
Preclinical evidence obtained through the use of selective tachykinin receptor antagonists indicates that endogenous tachyKinins are involved in augmented smooth muscle contraction, vasodilatation, chemotaxis and activation of immune cells, mucus secretion, water absorption/secretion. Expand
Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: Mechanism of action and biological response
Exposure to pH 6 solution of one half of the neck of guinea-pig urinary bladder induced a slowly developing inhibition of electrically evoked contractions, that was absent in the half pre-exposed in vitro to a desensitizing dose of capsaicin. Expand
Release of calcitonin gene-related peptide like-immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels
Findings provide direct evidence for a qualitative difference between central and peripheral endings of capsaicin-sensitive primary afferents in the mechanisms regulating transmitter release in the same species. Expand
Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats
Results indicate that COX‐1 may be involved in modulating the threshold for activating the micturition reflex in the normal rats and demonstrates that inhibition of COX-2 prevents or reverses the urodynamic changes associated with bladder inflammation induced either by surgery, LPS or CYP treatments. Expand
Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in guinea pigs
In the guinea pig ureter, substance P-(SP) and calcitonin gene-related peptide-(CGRP) like immunoreactivity (LI) were depleted by systemic capsaicin pretreatment, indicating that they are entirelyExpand
Pharmacological profile of the novel mammalian tachykinin, hemokinin 1
It is concluded that HEK‐1 is a full agonist at tachykinin NK1, NK2 and NK3 receptors, possesses a remarkable selectivity for NK1 as compared to NK2 orNK3 receptors and acts in vivo experiments with potency similar to that of SP. Expand
Capsaicin-desensitization to the human nasal mucosa selectively reduces pain evoked by citric acid.
The present results suggest that prolonged topical Capsaicin treatment to the human nasal mucosa may lead to selective desensitization to certain algesic stimuli such as capsaicin itself and hydrogen ions. Expand
Arachidonic acid and bradykinin share a common pathway to release neuropeptide from capsaicin-sensitive sensory nerve fibers of the guinea pig heart.
The ability of arachidonic acid (AA) and bradykinin to release calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from capsaicin-sensitive primary afferents was studied in guinea pigExpand
Tachykinin NK1receptor-mediated inhibitory responses in the guinea-pig small intestine
In the guinea-pig small intestine, NK 1 receptor stimulation evokes a myogenic excitatory motor response and a neurogenic inhibitory motor response that involves, at least in part, a nitrinergic pathway. Expand