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MDL 72527

Known as: MDL-72527, MDL-72527DA 
National Institutes of Health

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2 relations

Broader (1)

Putrescine
analogs & derivatives

Papers overview

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2016
2016
Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation
Background/Aims: The polyamine oxidase inhibitor MDL-72527 (N1,N4-bis(2,3-butadienyl)-1,4-butanediamine) were expected to… 
2006
2006
Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells.
Apple procyanidins have chemopreventive properties in a model of colon cancer, they affect intracellular signalling pathways, and… 
2004
2004
Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620
N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was considered to be a selective inactivator of FAD-dependent tissue… 
2003
2003
Small Interfering RNA Suppression of Polyamine Analog-Induced Spermidine / Spermine N 1-Acetyltransferase
N,N-diethylnorspermine (DENSPM) is a polyamine analog that down-regulates polyamine biosynthesis and potently upregulates the… 
2000
2000
Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity.
1998
1998
Effect of inhibitors of enzymes involved in polyamine biosynthesis pathway on pregnancy in mouse and hamster.
1998
1998
Polyamine metabolism of rat gastric mucosa after oral administration of hypertonic sodium chloride solution.
Oral administration of 1 ml of 3.42 M NaCl solution to rats induced spermidine/spermine N 1-acetyltransferase (SSAT) activity in… 
1998
1998
Polyamine metabolism of rat gastric mucosa after oral administration of hypertonic sodium chloride solution.
Oral administration of 1 ml of 3.42 M NaCl solution to rats induced spermidine/spermine N1-acetyltransferase (SSAT) activity in… 
1993
1993
Importance of various intracellular regulatory mechanisms of polyamine metabolism in camostate-induced pancreatic growth in rats.
Aim of the present study was to evaluate the relevance of various intracellular regulatory mechanisms of polyamine metabolism in… 
1990
1990
Inhibition of polyamine oxidase in rats improves the sensitivity of urinary polyamines as markers for cell death.
In this study we investigated polyamine metabolism during inhibition of two polyamine-catabolizing enzymes. This was performed by… 
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