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MCM complex

Known as: MCM complex location, mini-chromosome maintenance complex, mini-chromosome maintenance complex location 
A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

CMG complexpre-replicative complex location

Narrower (1)

MCM core complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2–7) forms the core of the eukaryotic replicative helicase… Expand
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Highly Cited
2015
Highly Cited
2015
Structure of the eukaryotic MCM complex at 3.8 Å
DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of… Expand
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Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.
Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of… Expand
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2011
2011
Molecular support for the recognition of the Mycoblastus fucatus group as the new genus Violella (Tephromelataceae, Lecanorales).
The crustose lichen genus Mycoblastus in the Northern Hemisphere includes eight recognized species sharing large, simple… Expand
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Highly Cited
2005
Highly Cited
2005
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric… Expand
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2005
2005
Interaction of hRad51 and hRad52 with MCM complex: a cross-talk between recombination and replication proteins.
Human Rad51 and Rad52 are implicated in DNA repair during replication. Here we show, by pull-down assays, that purified hRad51… Expand
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Highly Cited
2003
Highly Cited
2003
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45.
BACKGROUND MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show… Expand
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Review
2002
Review
2002
Control of DNA replication licensing in a cell cycle.
To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called… Expand
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Review
2001
Review
2001
Initiating DNA synthesis: from recruiting to activating the MCM complex.
The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal… Expand
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1999
1999
Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a… Expand
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