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MCM complex

Known as: MCM complex location, mini-chromosome maintenance complex, mini-chromosome maintenance complex location 
A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

CMG complexpre-replicative complex location

Narrower (1)

MCM core complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
DNA translocation mechanism of the MCM complex and implications for replication initiation
The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication… Expand
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Highly Cited
2017
Highly Cited
2017
Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2–7) forms the core of the eukaryotic replicative helicase… Expand
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Highly Cited
2015
Highly Cited
2015
Structure of the eukaryotic MCM complex at 3.8 Å
DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of… Expand
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Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.
Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of… Expand
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Highly Cited
2012
Highly Cited
2012
Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes
CCAAT/enhancer-binding protein (C/EBP) β is required for both mitotic clonal expansion (MCE) and terminal adipocyte… Expand
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Review
2005
Review
2005
The MCM complex: its role in DNA replication and implications for cancer therapy.
  • M. Lei
  • Current cancer drug targets
  • 2005
    • Corpus ID: 1324633
The MCM complex controls the once per cell cycle DNA replication in eukaryotic cells. In a process known as DNA replication… Expand
Highly Cited
2005
Highly Cited
2005
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric… Expand
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Highly Cited
2003
Highly Cited
2003
CDK‐ and Cdc45‐dependent priming of the MCM complex on chromatin during S‐phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45
Background: MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies… Expand
Review
2002
Review
2002
Control of DNA replication licensing in a cell cycle
To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called… Expand
Review
2001
Review
2001
Initiating DNA synthesis: from recruiting to activating the MCM complex.
  • M. Lei, B. Tye
  • Journal of cell science
  • 2001
    • Corpus ID: 14331263
The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal… Expand
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