MCM complex

Known as: MCM complex location, mini-chromosome maintenance complex, mini-chromosome maintenance complex location 
A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

CMG complexpre-replicative complex location

Narrower (1)

MCM core complex

Papers overview

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2017
2017
Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2–7) forms the core of the eukaryotic replicative helicase… (More)
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2015
2015
Structure of the eukaryotic MCM complex at 3.8 Ã…
DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of… (More)
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Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.
Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of… (More)
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2012
2012
Molecular architecture of a multifunctional MCM complex
DNA replication is strictly regulated through a sequence of steps that involve many macromolecular protein complexes. One of them… (More)
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Highly Cited
2005
Highly Cited
2005
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric… (More)
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2005
2005
Interaction of hRad51 and hRad52 with MCM complex: a cross-talk between recombination and replication proteins.
Human Rad51 and Rad52 are implicated in DNA repair during replication. Here we show, by pull-down assays, that purified hRad51… (More)
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2003
2003
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45.
BACKGROUND MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show… (More)
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Review
2002
Review
2002
Control of DNA replication licensing in a cell cycle.
To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called… (More)
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Review
2001
Review
2001
Initiating DNA synthesis: from recruiting to activating the MCM complex.
The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal… (More)
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1999
1999
Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a… (More)
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