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The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication… Expand The minichromosome maintenance complex (MCM) hexameric complex (Mcm2–7) forms the core of the eukaryotic replicative helicase… Expand DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of… Expand Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of… Expand CCAAT/enhancer-binding protein (C/EBP) β is required for both mitotic clonal expansion (MCE) and terminal adipocyte… Expand The MCM complex controls the once per cell cycle DNA replication in eukaryotic cells. In a process known as DNA replication… Expand The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric… Expand Background: MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies… Expand To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called… Expand The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal… Expand