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MCM complex
Known as:
MCM complex location
, mini-chromosome maintenance complex
, mini-chromosome maintenance complex location
A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
CMG complex
pre-replicative complex location
Narrower (1)
MCM core complex
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
DNA translocation mechanism of the MCM complex and implications for replication initiation
M. Meagher
,
L. B. Epling
,
E. J. Enemark
Nature Communications
2019
Corpus ID: 196810909
The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication…
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Highly Cited
2017
Highly Cited
2017
Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
Y. Zhai
,
E. Cheng
,
+4 authors
B. Tye
Nature Structural &Molecular Biology
2017
Corpus ID: 3929807
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2–7) forms the core of the eukaryotic replicative helicase…
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Highly Cited
2015
Highly Cited
2015
Structure of the eukaryotic MCM complex at 3.8 Å
Ningning Li
,
Y. Zhai
,
+5 authors
N. Gao
Nature
2015
Corpus ID: 4468690
DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of…
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Highly Cited
2014
Highly Cited
2014
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex
S. Hiraga
,
G. Alvino
,
+7 authors
A. Donaldson
Genes & Development
2014
Corpus ID: 206229459
Recent evidence points to a role for Rif1 (Rap1-interacting factor) in DNA replication and genomic stability; however, the…
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Review
2005
Review
2005
The MCM complex: its role in DNA replication and implications for cancer therapy.
M. Lei
Current Cancer Drug Targets
2005
Corpus ID: 1324633
The MCM complex controls the once per cell cycle DNA replication in eukaryotic cells. In a process known as DNA replication…
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Highly Cited
2005
Highly Cited
2005
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
A. McGeoch
,
M. Trakselis
,
R. Laskey
,
S. Bell
Nature Structural &Molecular Biology
2005
Corpus ID: 9621091
The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric…
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Highly Cited
2003
Highly Cited
2003
CDK‐ and Cdc45‐dependent priming of the MCM complex on chromatin during S‐phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45
T. Masuda
,
S. Mimura
,
H. Takisawa
Genes to Cells
2003
Corpus ID: 23140195
Background: MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies…
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Review
2002
Review
2002
Control of DNA replication licensing in a cell cycle
H. Nishitani
,
Z. Lygerou
Genes to Cells
2002
Corpus ID: 38068818
To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called…
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Review
2001
Review
2001
Initiating DNA synthesis: from recruiting to activating the MCM complex.
M. Lei
,
B. Tye
Journal of Cell Science
2001
Corpus ID: 14331263
The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal…
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Highly Cited
1999
Highly Cited
1999
Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
S. Pasion
,
S. Forsburg
Molecular Biology of the Cell
1999
Corpus ID: 1014934
The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a…
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