Corpus ID: 104183352

Functional Characterization of the MCM Complex Binding Protein, MCM-BP

@inproceedings{Jagannathan2014FunctionalCO,
  title={Functional Characterization of the MCM Complex Binding Protein, MCM-BP},
  author={Madhav Jagannathan},
  year={2014}
}
  • Madhav Jagannathan
  • Published 2014
  • Chemistry
  • Complete and accurate DNA replication is essential to maintain the genetic integrity in all organisms. In eukaryotes, the minichromosome maintenance (MCM) complex forms the catalytic core of the CMG helicase that unwinds DNA at the replication fork. We have previously identified a conserved MCM complex binding protein (MCM-BP) through a proteomic screen in human cells. In chapter two of this thesis, I show that MCM-BP makes an important contribution to nuclear morphology in human cells by… CONTINUE READING