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MCL1 protein, human

Known as: Bcl-2-Related Protein EAT/mcl1, mcl1/EAT, MCL1L protein, human 
Induced myeloid leukemia cell differentiation protein Mcl-1 (350 aa, ~37 kDa) is encoded by the human MCL1 gene. This protein is involved in the… 
National Institutes of Health

Related topics

Related topics

12 relations
ApoptosisApoptosis InhibitorBH1 DomainBH2 Domain

Broader (1)

Myeloid Cell Leukemia Sequence 1 Protein

Papers overview

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Highly Cited
2018
Highly Cited
2018
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
The prosurvival BCL2 family member MCL1 is frequently dysregulated in cancer. To overcome the significant challenges associated… 
Highly Cited
2018
Highly Cited
2018
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia.
Suppression of apoptosis by expression of antiapoptotic BCL2 family members is a hallmark of acute myeloblastic leukemia (AML… 
Highly Cited
2018
Highly Cited
2018
Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2… 
Review
2017
Review
2017
Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
The ERK1/2 signalling pathway is best known for its role in connecting activated growth factor receptors to changes in gene… 
Highly Cited
2016
Highly Cited
2016
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.
New therapeutic targets are needed to address the poor prognosis of patients with high-risk multiple myeloma. Myeloma cells… 
Highly Cited
2011
Highly Cited
2011
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover
Recent studies have revealed a role for the Ub/proteasome system in the regulation and turnover of OMM-associated proteins. The… 
Highly Cited
2011
Highly Cited
2011
Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA*
BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of… 
Highly Cited
2004
Highly Cited
2004
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
Mcl-1 is an antiapoptotic member of the Bcl-2 family that can promote cell viability. We report here that Mcl-1 is a new… 
Highly Cited
2002
Highly Cited
2002
Physical and Functional Interaction between Myeloid Cell Leukemia 1 Protein (MCL1) and Fortilin
Myeloid cell leukemia 1 protein (MCL1) is an anti-apoptotic protein that is structurally related to Bcl-2. Unlike other Bcl-2… 
Highly Cited
2000
Highly Cited
2000
Regulation of Apoptosis and Cell Cycle Progression by MCL1
MCL1 (ML1 myeloid cellleukemia 1), a Bcl-2 (B-cell lymphoma-leukemia 2) homologue, is known to function as an anti-apoptotic… 
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