Skip to search formSkip to main contentSkip to account menu

MAPKAPK5 gene

Known as: MAPKAPK5, p38-REGULATED/ACTIVATED KINASE, PRAK 
This gene is involved in protein phosphorylation, mTORC1-mediated signaling and tumor suppression.
National Institutes of Health

Related topics

Related topics

7 relations
Induction of Cell SenescenceMAP-kinase-activated kinase 5MAPKAPK5 protein, humanPhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
2019
2019
MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair.
MK5 is a protein serine/threonine kinase activated by p38, ERK3, and ERK4 MAPKs. MK5 mRNA and immunoreactivity are detected in… 
2016
2016
Pilot study of small bowel mucosal gene expression in patients with irritable bowel syndrome with diarrhea.
Prior studies in with irritable bowel syndrome with diarrhea (IBS-D) patients showed immune activation, secretion, and barrier… 
Review
2016
Review
2016
New insights into the activation, interaction partners and possible functions of MK5/PRAK.
MAP kinase-activated protein kinase 5 (MK5) was first described as a downstream target of the p38 MAP kinase pathway leading to… 
2015
2015
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
There is great interest in blood-based markers of Alzheimer’s disease (AD), especially in its pre-symptomatic stages. Therefore… 
2014
2014
Cross-Phosphorylation and Interaction between Src/FAK and MAPKAP5/PRAK in Early Focal Adhesions Controls Cell Motility.
P38-regulated and activated kinase (PRAK/MAPKAPK5) is a serine/threonine kinase which lies downstream of the p38 and ERK3/4 MAP… 
2012
2012
MK5 is degraded in response to doxorubicin and negatively regulates doxorubicin-induced apoptosis in hepatocellular carcinoma cells.
2011
2011
A matter of energy stress: p38β meets mTORC1
Throughout evolution, cells have developed sophisticated signaling mechanisms to balance the production and expenditure of energy… 
2010
2010
Characterization of the expression and regulation of MK5 in the murine ventricular myocardium.
Highly Cited
2005
Highly Cited
2005
p38 mitogen‐activated protein kinase (MAPK) first regulates filamentous actin at the 8–16‐cell stage during preimplantation development
Background information. The MAPK (mitogen‐activated protein kinase) superfamily of proteins consists of four separate signalling… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)