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MAPK8 wt Allele

Known as: JNK1, JNK1A2, PRKM8 
Human MAPK8 wild-type allele is located in the vicinity of 10q11.22 and is approximately 133 kb in length. This allele, which encodes mitogen… 
National Institutes of Health

Related topics

Related topics

49 relations
10q21.1ATM Signaling PathwayAdipocytokine Signaling PathwayAgrin Pathway

Broader (1)

MAPK8 gene

Papers overview

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2018
2018
Abstract 2675: Quinacrine-mediated activation of JNK1 inhibits Nrf2 and causes cell death in human colon cancer
Up-regulation of Nrf2 is associated with poor prognosis in skin, breast, prostate, lung, head and neck, endometrial, and… 
2014
2014
JNK1‑mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF‑α-‑induced apoptosis of HeLa cells.
The second mitochondria‑derived activator of caspases (Smac/DIABLO), is a mitochondrial protein that is released along with… 
2011
2011
Inhibition of JNK1 expression decreases migration and invasion of mouse hepatocellular carcinoma cell line in vitro
Abstractc-Jun N-terminal kinase (JNK) is located in focal adhesion plaque (FAP). JNK is necessary to growth, morphogenesis, and… 
2006
2006
JNK1, but not JNK2, is required for COX-2 induction by nickel compounds.
Activation of the signaling pathways leading to gene expression regulation is critical in the carcinogenic effects of nickel… 
2006
2006
Coordination of JNK1 and JNK2 Is Critical for GADD45α Induction and Its Mediated Cell Apoptosis in Arsenite Responses*
Arsenite is a well documented environmental pathogen, whereas it has also been applied as medication to treat various neoplasmas… 
2005
2005
JNK1 Is Essential for CD8+ T Cell-Mediated Tumor Immune Surveillance1
JNK1 has divergent roles in regulating the effector functions of CD4+ and CD8+ T cells. However, the function of JNK1 in tumor… 
2003
2003
Activation and role of MAP kinase-dependent pathways in retinal pigment epithelium cells: JNK1, P38 kinase, and cell death.
PURPOSE Retinal pigment epithelial (RPE) cell death is an important step in the pathogenesis of ocular diseases. JNK1 and P38… 
2003
2003
Effect of glucose concentration on activation of the ASK1–SEK1–JNK1 signal transduction pathway
Recently, acute total glucose deprivation has been shown to cause activation of ASK1–MEK–MAPK signal transduction and… 
2001
2001
Hyperthermia induces gene expression of heat shock protein 70 and phosphorylation of mitogen activated protein kinases in the rat cerebellum
2000
2000
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK…
The ability of low dose ionizing radiation (2 Gy) to modulate the activities of the mitogen activated protein kinase (MAPK) and c… 
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