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MAPK8 gene

Known as: STRESS-ACTIVATED PROTEIN KINASE JNK1, JNK, SAPK1 
This gene plays a role in signal transduction that affects cell differentiation, growth and proliferation. It is also involved in mediation of both… 
National Institutes of Health

Related topics

Related topics

14 relations
ApoptosisCell Cycle ControlCell Differentiation processJNK Mitogen-Activated Protein Kinases

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MAPK8 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
c-Jun N-terminal Kinase 1 (JNK1) Is Required for Coordination of Netrin Signaling in Axon Guidance*
Background: The JNK pathway is essential for brain development. Results: JNK1 plays an important role in Netrin-1-mediated axon… 
2010
2010
Novel roles for JNK1 in metabolism
Activation of stress-kinase signaling has recently been recognized as an important pathophysiological mechanism in the… 
Highly Cited
2009
Highly Cited
2009
PI3K p110β Positively Regulates Lipopolysaccharide-Induced IL-12 Production in Human Macrophages and Dendritic Cells and JNK1 Plays a Novel Role1
The PI3K family is thought to participate in TLR signaling, and it has been reported to be a negative regulator of TLR-mediated… 
2006
2006
JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.
2004
2004
AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan.
Literature suggests the involvement of the renin-angiotensin system and transforming growth factor (TGF)-beta in the renal injury… 
Highly Cited
1999
Highly Cited
1999
Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases
The E2F transcription factor plays a major role in cell cycle regulation, differentiation and apoptosis, but it is not clear how… 
Highly Cited
1999
Highly Cited
1999
Different Mechanisms of c-Jun NH2-terminal Kinase-1 (JNK1) Activation by Ultraviolet-B Radiation and by Oxidative Stressors*
Irradiation of mammalian cells with ultraviolet-B radiation (UV-B) triggers the activation of a group of stress-activated protein… 
Highly Cited
1998
Highly Cited
1998
Immunolocalization of the mitogen‐activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system
Cell survival, death, and stress signals are transduced from the cell surface to the cytoplasm and nucleus via a cascade of… 
Highly Cited
1998
Highly Cited
1998
Guanine-Nucleotide Exchange Protein C3G Activates JNK1 by a Ras-independent Mechanism
Recently we have reported that the adaptor protein Crk transmits signals to c-Jun kinase (JNK) through C3G, a guanine-nucleotide… 
Highly Cited
1997
Highly Cited
1997
Ras-dependent Activation of c-Jun N-terminal Kinase/Stress-activated Protein Kinase in Response to Interleukin-3 Stimulation in Hematopoietic BaF3 Cells*
Activation of the c-Jun N-terminal kinase (JNK)/stress-activated protein kinase pathway in response to stimulation of the… 
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