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MAP4K4 gene

Known as: Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Gene, MAP4K4, HPK/GCK-like kinase 
This gene is plays a role in signal transduction and is putatively involved in the transformation of cells.
National Institutes of Health

Related topics

Related topics

8 relations
MAP3K14 geneMAP4K4 protein, humanPhosphorylationSerine/Threonine Phosphorylation

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MAP4K4 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
[Let-7 miRNA silencing promotes Kaposi's sarcoma-associated herpesvirus lytic replication via activating mitogen-activated protein kinase kinase kinase kinase 4 and its downstream factors].
  • J. ZhangX. Tan L. Yang
  • Zhonghua zhong liu za zhi [Chinese journal of…
  • 2016
  • Corpus ID: 39100070
OBJECTIVE To explore the effect of let-7 miRNA silencing on Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication and… 
Highly Cited
2015
Highly Cited
2015
MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4.
MicroRNAs (miRNAs) play a crucial role in cancer development and progression of hepatocellular carcinoma (HCC). In this study, we… 
2014
2014
12 MAP4K4 as a Therapeutic Target in Cardiomyocyte Death: Novel inhibitors Identified through Pharmacophore Modelling and Virtual Screening
Ratonale Though reperfusion therapies have transformed treatment of myocardial infarction, no established treatments directly… 
2014
2014
Alternative Splicing Is a Frequent Event and Impacts Clinical Outcome in Myeloma: A Large RNA-Seq Data Analysis of Newly-Diagnosed Myeloma Patients
Alternative splicing is an important post-translational change that alters gene function. Misregulation of alternative splicing… 
2013
2013
The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells
Kaposi's sarcoma (KS) is a mesenchymal tumour, which is caused by Kaposi's sarcoma herpesvirus (KSHV) and develops under… 
2010
2010
Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2.
AIM To investigate the effects of RNA interference targeting hepatocyte progenitor kinase-like kinase (HGK) in the invasion and… 
Highly Cited
2009
Highly Cited
2009
Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-α-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion*
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the… 
Review
2008
Review
2008
Expression of MAP 4 K 4 Is Associated withWorse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
  • 2008
  • Corpus ID: 26296
Purpose: Mitogen-activated protein 4 kinase 4 (MAP4K4) is a serine/threonine kinase and belongs to the mammalian STE20/MAP4K… 
2006
2006
High-Molecular-Weight Kininogen Fragments Stimulate the Secretion of Cytokines and Chemokines Through uPAR , Mac-1 , and gC 1 qR in Monocytes
Objective—Plasma high-molecular-weight kininogen (HK) is cleaved in inflammatory diseases by kallikrein to HKa with release of… 
2006
2006
Rewriting game theory applied to protein signalling in MAPK cascades
We propose the recent notion of rewriting game theory as a tool for studying biochemical systems. Rewriting game theory is based… 
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