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The hepatitis C virus (HCV) pandemic affects the health of more than 170 million people and is the major indication for orthotopic liver transplantations. Although the human liver is the primary site for HCV replication, it is not known whether extrahepatic tissues are also infected by the virus and whether nonprimate cells are permissive for RNA(More)
A new heuristic algorithm is presented for constructing minimum-cost multicast trees with delay constraints. The new algorithm can set variable delay bounds on destinations and handles two variants of the network cost optimization goal: one minimizing the total cost (total bandwidth utilization) of the tree, and another minimizing the maximal link cost (the(More)
The bounded shortest multicast algorithm (BSMA) is presented for constructing minimum-cost multicast trees with delay constraints. BSMA can handle asymmetric link characteristics and variable delay bounds on destinations, speciied as real values and minimizes the total cost of a multicast routing tree. Instead of the single-pass tree construction approach(More)
We used an adjoint version of the process-based Terrestrial Ecosystem Model (TEM) to optimize the model parameters in a spatially explicit manner by assimilating satellite-based estimates of gross primary production (GPP) in the conterminous United States. Traditionally, terrestrial ecosystem model parameterization is conducted at site-level for various(More)
Second Life supports rich communication, virtual collaboration, and 3-D content creation. The Second Life synthetic world has great potential for teaching and learning. There are hundreds of universities all over the world pay attention to the engaging teaching and learning aids and effective research tools in Second Life. For faculty members to adopt(More)
Keywords: iOS m-Health applications Mobile development platforms a b s t r a c t Modern smart mobile devices offer media-rich and context-aware features that are highly useful for electronic-health (e-health) applications. It is therefore not surprising that these devices have gained acceptance as target devices for e-health applications, turning them into(More)
Estradiol enhances the formation of dendritic spines and excitatory synapses in hippocampal neurons in vitro and in vivo, but the underlying mechanisms are not fully understood. Kalirin-7 (Kal7), the major isoform of Kalirin in the adult hippocampus, is a Rho GDP/GTP exchange factor localized to postsynaptic densities. In the hippocampus, both Kal7 and(More)
Neural stem cell (NSC) transplantation has the potential to treat neurodegenerative diseases such as Parkinson's disease (PD). In this study, we investigated the effect of transplanted NSCs in a PD animal model. NSCs isolated from the subventricular zone (SVZ) of E14 rats were cultured in vitro to produce neurospheres, which were subsequently infected with(More)