FAQ

MAN1B1 gene

Known as: endoplasmic Reticulum Class I alpha-mannosidase, MAN1B1, Man9GlcNAc2-specific processing alpha-mannosidase 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
012320032017

Related topics

Related topics

3 relations
Alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Related mentions per year

Related mentions per year

1956-2018
1960198020002020
MAN1B1 gene
Alpha-mannosidase
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase

Papers overview

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2015
2015
Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates
Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD… (More)
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2014
2014
A Golgi-localized mannosidase (MAN1B1) plays a non-enzymatic gatekeeper role in protein biosynthetic quality control.
Conformation-based disorders are manifested at the level of protein structure, necessitating an accurate understanding of how… (More)
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2014
2014
Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency.
Congenital disorders of glycosylation comprise a group of genetic defects with a high frequency of intellectual disability… (More)
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2013
2013
MAN1B1 Deficiency: An Unexpected CDG-II
Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, due to impaired protein and lipid… (More)
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2013
2013
Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP
Endoplasmic reticulum (ER) α-1, 2-mannosidase (ERManI) contributes to ER-associated protein degradation (ERAD) by initiating the… (More)
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2012
2012
Ubiquitin-proteasomal degradation of COX-2 in TGF-β stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I.
Cyclooxygenase (COX)-2 is a key regulatory enzyme in the production of prostaglandins (PG) during various physiological processes… (More)
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2011
2011
Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability.
We have used genome-wide genotyping to identify an overlapping homozygosity-by-descent locus on chromosome 9q34.3 (MRT15) in four… (More)
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2011
2011
Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps.
Although the trimming of α1,2-mannose residues from precursor N-linked oligosaccharides is an essential step in the delivery of… (More)
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2011
2011
Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
The Golgi complex has been implicated as a possible component of endoplasmic reticulum (ER) glycoprotein quality control… (More)
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Highly Cited
2003
Highly Cited
2003
Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.
The exocytic pathway provides a physical route through which newly synthesized secretory and membrane proteins are deployed to… (More)
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