Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

MAN1B1 gene

Known as: endoplasmic Reticulum Class I alpha-mannosidase, MAN1B1, Man9GlcNAc2-specific processing alpha-mannosidase 
 
National Institutes of Health

Related topics

Related topics

3 relations
Alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation.
Innate immunity provides an immediate defense against infection after host cells sense danger signals from microbes. Endoplasmic… Expand
Is this relevant?
2015
2015
Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates
Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
A Golgi-localized Mannosidase (MAN1B1) Plays a Non-enzymatic Gatekeeper Role in Protein Biosynthetic Quality Control*
Background: The capacity of Golgi-localized MAN1B1 to promote ERAD was investigated. Results: The MAN1B1 catalytic domain is… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency.
Congenital disorders of glycosylation comprise a group of genetic defects with a high frequency of intellectual disability… Expand
  • figure 1
  • table 1
  • figure 2
Is this relevant?
2013
2013
MAN1B1 Deficiency: An Unexpected CDG-II
Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, due to impaired protein and lipid… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability.
We have used genome-wide genotyping to identify an overlapping homozygosity-by-descent locus on chromosome 9q34.3 (MRT15) in four… Expand
Is this relevant?
2011
2011
Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
The current study provides mechanistic insight into the overlapping dynamics by which glycoprotein folding and quality control… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.
We had previously shown that endoplasmic reticulum (ER)-associated degradation (ERAD) of glycoproteins in mammalian cells… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
2006
2006
Family 47 alpha-mannosidases in N-glycan processing.
Alpha-mannosidases in eukaryotic cells are involved in both glycan biosynthetic reactions and glycan catabolism. Two broad… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis.
We report the isolation of a novel human cDNA encoding a type II membrane protein of 79.5 kDa with amino acid sequence similarity… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE