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MAN1B1 gene

Known as: endoplasmic Reticulum Class I alpha-mannosidase, MAN1B1, Man9GlcNAc2-specific processing alpha-mannosidase 
 
National Institutes of Health

Related topics

Related topics

3 relations
Alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates
ER mannosidase I (ERManI) was found recently in the Golgi. This result is found to arise artificially from membrane disturbance… Expand
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2013
2013
Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP
Endoplasmic reticulum (ER) α-1, 2-mannosidase and γ-COP contribute to a Golgi-based quality control module that facilitates the… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability.
We have used genome-wide genotyping to identify an overlapping homozygosity-by-descent locus on chromosome 9q34.3 (MRT15) in four… Expand
Highly Cited
2011
Highly Cited
2011
Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
The current study provides mechanistic insight into the overlapping dynamics by which glycoprotein folding and quality control… Expand
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Highly Cited
2008
Highly Cited
2008
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.
We had previously shown that endoplasmic reticulum (ER)-associated degradation (ERAD) of glycoproteins in mammalian cells… Expand
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2006
2006
Family 47 alpha-mannosidases in N-glycan processing.
Alpha-mannosidases in eukaryotic cells are involved in both glycan biosynthetic reactions and glycan catabolism. Two broad… Expand
Review
2001
Review
2001
Structure and function of Class I alpha 1,2-mannosidases involved in glycoprotein synthesis and endoplasmic reticulum quality control.
Class I alpha 1,2-mannosidases (glycosylhydrolase family 47) are conserved through eukaryotic evolution. This protein family… Expand
Highly Cited
1999
Highly Cited
1999
Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis.
We report the isolation of a novel human cDNA encoding a type II membrane protein of 79.5 kDa with amino acid sequence similarity… Expand
1996
1996
The Saccharomyces cerevisiae processing alpha 1,2-mannosidase is localized in the endoplasmic reticulum, independently of known retrieval motifs.
The yeast-specific alpha 1,2-mannosidase, Mns1p, converts Man,GlcNAc2 to a single isomer of Man8GlcNAc2 during N-linked… Expand
Highly Cited
1989
Highly Cited
1989
Characterization of trimming Man9-mannosidase from pig liver. Purification of a catalytically active fragment and evidence for the transmembrane nature of the intact 65 kDa enzyme.
An alpha 1,2-mannosidase (Man9-mannosidase) involved in N-linked oligosaccharide processing has been purified about 16,000-fold… Expand
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