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MAN1B1 gene

Known as: endoplasmic Reticulum Class I alpha-mannosidase, MAN1B1, Man9GlcNAc2-specific processing alpha-mannosidase 
National Institutes of Health

Related topics

Related topics

3 relations
Alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidasemannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation
ABSTRACT Innate immunity provides an immediate defense against infection after host cells sense danger signals from microbes… 
Highly Cited
2013
Highly Cited
2013
Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP
Endoplasmic reticulum (ER) α-1, 2-mannosidase and γ-COP contribute to a Golgi-based quality control module that facilitates the… 
Highly Cited
2011
Highly Cited
2011
Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system
The current study provides mechanistic insight into the overlapping dynamics by which glycoprotein folding and quality control… 
Highly Cited
2008
Highly Cited
2008
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.
We had previously shown that endoplasmic reticulum (ER)-associated degradation (ERAD) of glycoproteins in mammalian cells… 
2006
2006
Family 47 alpha-mannosidases in N-glycan processing.
Alpha-mannosidases in eukaryotic cells are involved in both glycan biosynthetic reactions and glycan catabolism. Two broad… 
Review
2001
Review
2001
Structure and function of Class I alpha 1,2-mannosidases involved in glycoprotein synthesis and endoplasmic reticulum quality control.
Highly Cited
1999
Highly Cited
1999
Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis.
We report the isolation of a novel human cDNA encoding a type II membrane protein of 79.5 kDa with amino acid sequence similarity… 
Review
1997
Review
1997
Phylogenetic survey of endomannosidase indicates late evolutionary appearance of this N-linked oligosaccharide processing enzyme.
Endo-alpha-D-mannosidase is a processing enzyme which in contrast to other glycosidases involved in the trimming of N-linked… 
1996
1996
The Saccharomyces cerevisiae processing alpha 1,2-mannosidase is localized in the endoplasmic reticulum, independently of known retrieval motifs.
The yeast-specific alpha 1,2-mannosidase, Mns1p, converts Man,GlcNAc2 to a single isomer of Man8GlcNAc2 during N-linked… 
Highly Cited
1989
Highly Cited
1989
Characterization of trimming Man9-mannosidase from pig liver. Purification of a catalytically active fragment and evidence for the transmembrane nature of the intact 65 kDa enzyme.
An alpha 1,2-mannosidase (Man9-mannosidase) involved in N-linked oligosaccharide processing has been purified about 16,000-fold… 
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