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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
The data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.
E3 ubiquitin ligase that recognizes sugar chains
It is reported that N-glycan serves as a signal for degradation by the Skp1–Cullin1–Fbx2–Roc1 (SCFFbx 2) ubiquitin ligase complex, which ubiquitinates N- Glycosylated proteins that are translocated from the ER to the cytosol by the quality control mechanism.
Substrate Specificity Analysis of Endoplasmic Reticulum Glucosidase II Using Synthetic High Mannose-type Glycans*
- K. Totani, Y. Ihara, I. Matsuo, Yukishige Ito
- Biology, ChemistryJournal of Biological Chemistry
- 20 October 2006
In the presence of CRT, Glc'ase II-mediated trimming from Glc2Man 9GlcNAc2 stopped at Glc1Man9Glc NAc2, supporting the notion that the glycan structure delivered to the CNX/CRT cycle is Glc 1Man9 GlcNAC2.
The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2.
It is demonstrated that the binding of ERGIC-53 to sugar is enhanced by its interaction with MCFD2, and defects in this interaction in F5F8D patients may be the cause for reduced secretion of factors V and VIII.
Sugar-binding Properties of VIP36, an Intracellular Animal Lectin Operating as a Cargo Receptor*
It is suggested that VIP36 binds glycoproteins that retain the intact D1 mannosyl branch in the cis-Golgi network and recycles to the endoplasmic reticulum where, due to higher pH, it releases its cargos, thereby contributing to the quality control of glyCoproteins.
Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord
Findings show that LysoPtdGlc/GPR55 is a lipid-based signaling system in glia-neuron communication for neural development, and its role in modality-specific repulsive guidance of spinal cord sensory axons is demonstrated.
The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation.
Results suggest that trimming of the outermost alpha1,2-linked mannose on the C-arm is a critical process for misfolded proteins to enter ERAD.
Functional analysis of endoplasmic reticulum glucosyltransferase (UGGT): Synthetic chemistry's initiative in glycobiology.
Analysis of the sugar‐binding specificity of mannose‐binding‐type Jacalin‐related lectins by frontal affinity chromatography – an approach to functional classification
A detailed comparison of sugar‐binding specificity was made by frontal affinity chromatography to corroborate the structure–function relationships of the extended mJRL subfamily and shed light on the functional significance of JRLs.