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Substrate Specificity Analysis of Endoplasmic Reticulum Glucosidase II Using Synthetic High Mannose-type Glycans*
TLDR
In the presence of CRT, Glc'ase II-mediated trimming from Glc2Man 9GlcNAc2 stopped at Glc1Man9Glc NAc2, supporting the notion that the glycan structure delivered to the CNX/CRT cycle is Glc 1Man9 GlcNAC2.
The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2.
TLDR
It is demonstrated that the binding of ERGIC-53 to sugar is enhanced by its interaction with MCFD2, and defects in this interaction in F5F8D patients may be the cause for reduced secretion of factors V and VIII.
Sugar-binding Properties of VIP36, an Intracellular Animal Lectin Operating as a Cargo Receptor*
TLDR
It is suggested that VIP36 binds glycoproteins that retain the intact D1 mannosyl branch in the cis-Golgi network and recycles to the endoplasmic reticulum where, due to higher pH, it releases its cargos, thereby contributing to the quality control of glyCoproteins.
A novel glucuronoyl esterase from Aspergillus fumigatus—the role of conserved Lys residue in the preference for 4-O-methyl glucuronoyl esters
TLDR
Molecular modeling and site-directed mutagenesis studies of AfGE demonstrated that Lys209 plays an important role in the preference for the substrates containing 4-O-methyl group in the glucopyranose ring.
Effects of macromolecular crowding on glycoprotein processing enzymes.
TLDR
The results indicate that the kinetics of glycan processing under crowded conditions may be quite different from those measured in dilute buffers.
The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc:glycoprotein glucosyltransferase.
TLDR
The comparison of the reactivity of acceptors that have been modified by various aglycons supports the hypothesis that UGGT recognizes the hydrophobic region of client glycoproteins, and discovered fluorescently labeled substrates that will be valuable for highly sensitive detection of U GGT activity.
Peroxisomes Are Involved in Biotin Biosynthesis in Aspergillus and Arabidopsis*
TLDR
A novel role for peroxisomes in biotin biosynthesis is demonstrated and the presence of as yet unidentified peroxISomal proteins that function in the earlier steps ofBiotin biosynthetic enzymes is suggested.
Evidence for an Essential Deglycosylation-Independent Activity of PNGase in Drosophila melanogaster
TLDR
Pngl was shown to be inevitable for the proper developmental transition and the biochemical properties other than deglycosylation activity is important for its biological function.
Identification and Characterization of an Intracellular Lectin, Calnexin, from Aspergillus oryzae Using N-Glycan-Conjugated Beads
TLDR
The results suggest that the affinity chromatography with synthetic N-glycans might help in biological analysis of glycoprotein quality control in the ER.
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