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Long Interspersed Nucleotide Element-1

Known as: L1 Element, Elements, LINE-1, L1 
A long interspersed element (LINE) found in mammals. The LINE-1 element is the only active LINE in humans and is approximately 6,000 base pairs long… 
National Institutes of Health

Related topics

Related topics

2 relations
Chromosomes

Broader (1)

Long Interspersed Elements

Papers overview

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Highly Cited
2007
Highly Cited
2007
LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability
Background Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not… 
Highly Cited
2006
Highly Cited
2006
APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition*
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that… 
Review
2006
Review
2006
Methylation of endogenous human retroelements in health and disease.
Retroelements constitute approximately 45% of the human genome. Long interspersed nuclear element (LINE) autonomous… 
Highly Cited
2005
Highly Cited
2005
NF-κB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program
Activation of the transcription factor NF-κB is critical for the tumor necrosis factor-α (TNF-α)-induced inflammatory response… 
Highly Cited
2003
Highly Cited
2003
An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4
The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation… 
Highly Cited
2002
Highly Cited
2002
Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements
ABSTRACT We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA methyltransferases to delineate the roles… 
Highly Cited
2001
Highly Cited
2001
Genome-wide hypomethylation in hepatocellular carcinogenesis.
Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis. However, its mechanism and implications in… 
Highly Cited
2000
Highly Cited
2000
L1 (LINE-1) retrotransposon evolution and amplification in recent human history.
L1 (LINE-1) elements constitute a large family of mammalian retrotransposons that have been replicating and evolving in mammals… 
Highly Cited
1992
Highly Cited
1992
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with… 
Highly Cited
1988
Highly Cited
1988
Unit-length line-1 transcripts in human teratocarcinoma cells
We have characterized the approximately 6.5-kilobase cytoplasmic poly(A)+ Line-1 (L1) RNA present in a human teratocarcinoma cell… 
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