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Lidoflazine

Known as: 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-, Lidoflazine [Chemical/Ingredient] 
Coronary vasodilator with some antiarrhythmic action.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Calcium Channel BlockersVasodilator Agents

Narrower (1)

Clinium
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Drug-induced prolongation of the QT interval.
  • D. Roden
  • The New England journal of medicine
  • 2004
  • Corpus ID: 15251057
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation… 
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Highly Cited
2003
Highly Cited
2003
Detection of Proarrhythmia in the Female Rabbit Heart:
Introduction: Reliable detection of drug‐induced proarrhythmia, especially the potential for polymorphic ventricular tachycardia… 
Highly Cited
1997
Highly Cited
1997
Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.
Mammalian equilibrative nucleoside transporters are typically divided into two classes, es and ei, based on their sensitivity or… 
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Highly Cited
1991
Highly Cited
1991
A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest.
BACKGROUND Abnormalities of cellular calcium homeostasis have been implicated in the pathophysiology of postischemic… 
Highly Cited
1988
Highly Cited
1988
Comparative protective effects of nicardipine, flunarizine, lidoflazine and nimodipine against ischaemic injury in the hippocampus of the Mongolian gerbil
1 Morphological changes characterizing delayed neuronal death (DND) of selectively vulnerable CA1 pyramidal cells in the… 
Highly Cited
1987
Highly Cited
1987
Cerebral Ischemia and Reperfusion: Prevention of Brain Mitochondrial Injury by Lidoflazine
Mitochondrial degradation is implicated in the irreversible cell damage that can occur during cerebral ischemia and reperfusion… 
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Highly Cited
1984
Highly Cited
1984
Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs
Calcium entry blockers can ameliorate postischemic cerebral hypoperfusion, protect the myocardium against ischemia, and may… 
Highly Cited
1983
Highly Cited
1983
Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.
A chemically heterogeneous group of compounds, the Ca++ channel antagonists, which includes verapamil, diltiazem and nifedipine… 
Highly Cited
1981
Highly Cited
1981
Cardioprotective Effects of Lidoflazine During 1‐hour Normothermic Global Ischemia
The cardioprotective effects of lidofiazine, a drug with calcium homeostatic properties, were investigated in dogs subjected to 1… 
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Highly Cited
1972
Highly Cited
1972
Left Ventricular Stress and Compliance in Man: With Special Reference to Normalized Ventricular Function Curves
Left ventricular circumferential end-diastolic stress (Sed), peak systolic stress (Sps), and compliance at end-diastole ([dV/VdP… 
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