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Q‐ and L‐type Ca2+ channels dominate the control of secretion in bovine chromaffin cells
Potassium‐stimulated catecholamine release from superfused bovine adrenal chromaffin cells (70 mM K+ in the presence of 2 mM Ca2+ for 10 s, applied at 5‐min intervals) was inhibited by theExpand
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Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells
Abstract This study uses a new strategy to investigate the hypothesis that, of the various Ca2+ channels expressed by a neurosecretory cell, a given channel subtype is coupled more tightly to theExpand
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A caffeine-sensitive Ca2+ store modulates K+-evoked secretion in chromaffin cells.
Catecholamine release from bovine adrenal medulla chromaffin cells superfused with a Krebs-N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid solution was monitored on-line with an electrochemicalExpand
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Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells
1 Otilonium, a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR) as well as a mild wide‐spectrum Ca2+ channel blocker in bovine adrenalExpand
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Autocrine/paracrine modulation of calcium channels in bovine chromaffin cells
Abstract Applying 10-s pulses of 10 mM Ba2+ to resting or K+-depolarized (70 mM) bovine adrenal chromaffin cells superfused with a nominal 0Ca2+ solution produced a large catecholamine secretoryExpand
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Dotarizine versus flunarizine as calcium antagonists in chromaffin cells
1 Dotarizine is a novel piperazine derivative structurally related to flunarizine that is currently being evaluated in clinical trials for its antimigraine and antivertigo effects. This clinicalExpand
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Drastic facilitation by α‐latrotoxin of bovine chromaffin cell exocytosis without measurable enhancement of Ca2+ entry or [Ca2+]i
1 Latrotoxin (LTX, 1–3 nm) caused a gradual increase of the supontaneous catecholamine release rate in bovine adrenal chromaffin cells superfused with normal Krebs–Hepes solution containing 2.5 mmExpand
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Analogies and differences between ω-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells
Abstract The characteristics of the binding sites for the Conus magus toxins ω-conotoxin MVIIC and ω-conotoxin MVIID, as well as their effects on K+-evoked 45Ca2+ entry and whole-cell Ba2+ currentsExpand
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Density of apamin-sensitive Ca(2+)-dependent K+ channels in bovine chromaffin cells: relevance to secretion.
Three objectives were defined when planning this study: (i) to identify binding sites for [125I]-apamin in intact bovine adrenal medulla chromaffin cells and to estimate their density andExpand
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Hypertensinogenic factors and renal α-adrenoceptors in young SHR and WKY rats
Abstract The effects of high sodium intake (drinking 1% NaCl), DOCA and DOCA + 1%NaCl for 6 weeks on renal α 1 - and α 2 - adrenoceptors and on systolic blood pressure (SBP) were examined in youngExpand
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