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Opioid Inhibition of Ca2+ Channel Subtypes in Bovine Chromaffin Cells: Selectivity of Action and Voltage‐dependence
Bovine chromaffin cells possess a mixture of high‐voltage‐activated Ca2+ channel subtypes: L‐type, dihydropyridine‐sensitive channels, and N‐, P‐ and Q‐types, ω‐conotoxin MVIIC‐sensitive channels. InExpand
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Sphingosine Facilitates SNARE Complex Assembly and Activates Synaptic Vesicle Exocytosis
Summary Synaptic vesicles loaded with neurotransmitters fuse with the plasma membrane to release their content into the extracellular space, thereby allowing neuronal communication. The membraneExpand
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Q‐ and L‐type Ca2+ channels dominate the control of secretion in bovine chromaffin cells
Potassium‐stimulated catecholamine release from superfused bovine adrenal chromaffin cells (70 mM K+ in the presence of 2 mM Ca2+ for 10 s, applied at 5‐min intervals) was inhibited by theExpand
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Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells
Abstract This study uses a new strategy to investigate the hypothesis that, of the various Ca2+ channels expressed by a neurosecretory cell, a given channel subtype is coupled more tightly to theExpand
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Multiple calcium channel subtypes in isolated rat chromaffin cells
By using the whole-cell configuration of the patch-clamp technique we have investigated the pharmacological properties of Ca2+ channels in short-term cultured rat chromaffin cells. In cells held at aExpand
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Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
BACKGROUND & AIMS Although smoking is a leading risk factor for pancreatic ductal adenocarcinoma (PDAC), little is known about the mechanisms by which smoking promotes initiation or progression ofExpand
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Localized L-type calcium channels control exocytosis in cat chromaffin cells
Depolarizing 1-s pulses to 0 mV from a holding potential of −70 mV, induced whole-cell currents through Ca2+ channels (ICa) in patch-clamped cat adrenal medulla chromaffin cells. The dihydropyridineExpand
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Voltage inactivation of Ca2+ entry and secretion associated with N‐ and P/Q‐type but not L‐type Ca2+ channels of bovine chromaffin cells
1 In this study we pose the question of why the bovine adrenal medullary chromaffin cell needs various subtypes (L, N, P, Q) of the neuronal high‐voltage activated Ca2+ channels to control a givenExpand
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Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly
The synthesis, biological assessment, and molecular modelling of new tacrine analogues 11-22 is described. Compounds 11-22 have been obtained by Friedländer-type reaction ofExpand
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Permeation by zinc of bovine chromaffin cell calcium channels: relevance to secretion
Zn2+ increased the rate of spontaneous release of catecholamines from bovine adrenal glands. This effect was Ca2+ independent; in fact, in the absence of extracellular Ca2+, the secretory effects ofExpand
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