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Calcium signaling and exocytosis in adrenal chromaffin cells.
TLDR
It is proposed that chromaffin cells have developed functional triads that are formed by calcium channels, the ER, and the mitochondria and locally control the [Ca2+]c that regulate the early and late steps of exocytosis.
Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission
TLDR
It is suggested that GABA release is modulated by α7 nAChRs, which could have potential therapeutic applications in brain disorders such as epilepsy and schizophrenia and in alterations of cognition and sensory processing.
A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla
TLDR
The tight neural control of the differential secretion into the circulation, of the adrenal medullary hormones adrenaline and noradrenaline is reviewed and some recent experiments using ultrashort ACh pulses, that cause non‐desensitizing repetitive APs with each ACh pulse, at low ACh concentrations, are presented.
Dihydropyridine BAY-K-8644 activates chromaffin cell calcium channels
TLDR
The experiments described here strongly suggest that BAY-K-8644 behaves as a Ca2+-channel activator at the chromaffin cell membrane as shown by Schramm et al.5 in smooth muscle cells.
Opioid Inhibition of Ca2+ Channel Subtypes in Bovine Chromaffin Cells: Selectivity of Action and Voltage‐dependence
TLDR
A functionally distinct opioid receptor‐mediated modulation of L‐ and non‐L‐type channels, i.e. of the two channel classes sharing major control of catecholamine secretion from bovine chromaffin cells, is suggested.
Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
TLDR
The present results constitute the first evidence to support a prominent role of alpha7 nAChR in controlling such functions, specially under the more physiological conditions used here to stimulate chromaffin cells with brief pulses of ACh.
A caffeine-sensitive Ca2+ store modulates K+-evoked secretion in chromaffin cells.
TLDR
Functional data are compatible with the view that the degree of filling of a caffeine-sensitive intracellular Ca2+ store might regulate the extent of exocytosis, and the depression of secretion by caffeine does not seem to be associated with inhibition of extracellular Ca 2+ entry through Ca2- channels.
Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca2+ signalling in hippocampal neurons
TLDR
The pharmacological profile suggests that the neuroprotective effects of minocycline might be associated with the mitigation of neuronal excitability, glutamate release, and Ca2+ overloading.
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