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Licensing Factor

S-phase onset is controlled, so that it occurs only once every cell cycle. DNA is licensed for replication after mitosis in G(1), and passage through… 
National Institutes of Health

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7 relations
Cell Cycle ControlDNA Replication FactorGenes, RegulatorGenes, cdc

Papers overview

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2013
2013
The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing*
Background: Idas is a homologue of the proliferation and differentiation regulator, Geminin. Results: Idas and Geminin form… 
2010
2010
Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells
Cyclin E-associated CDK2 activity is required for the initiation of DNA synthesis in human cells. CDK2 activity is tightly… 
2009
2009
Visualization of radiation-induced cell cycle-associated events in tumor cells expressing the fusion protein of Azami Green and the destruction box of human Geminin.
2007
2007
A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions.
Phosphorylation-dependent protein-protein interactions provide the mechanism for a large number of intracellular signal… 
2007
2007
The Mre11/Rad50/Nbs1 Complex Plays an Important Role in the Prevention of DNA Rereplication in Mammalian Cells*
The Mre11/Nbs1/Rad50 complex (MRN) plays multiple roles in the maintenance of genome stability, including repair of double… 
Highly Cited
2005
Highly Cited
2005
Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer.
Licensing of chromatin for replication is an evolu-tionarily conserved step in the control of cell division and genomic integrity… 
Highly Cited
2002
Highly Cited
2002
Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic… 
1997
1997
HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5
The tight regulatory mechanism that prevents more than one round of chromosomal DNA replication per cell cycle is thought to… 
Highly Cited
1997
Highly Cited
1997
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
The mechanism of megakaryocytic differentiation was investigated using human megakaryocytic leukemia cell line UT-7… 
Highly Cited
1993
Highly Cited
1993
Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor
We have investigated the mechanism which prevents reinitiation of DNA replication within a single cell cycle by exploiting the… 
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