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Leupeptins

Known as: Leupeptins [Chemical/Ingredient] 
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees… 
National Institutes of Health

Related topics

Related topics

16 relations
In BloodProcess of secretionagonistsantagonists & inhibitors

Broader (1)

Protease Inhibitors

Narrower (7)

acetyl-leucinyl-leucinyl-methionalacetylleucyl-leucyl-norleucinalbenzyloxycarbonylleucyl-leucyl-leucine aldehydecarbobenzoxy-leucyl-leucyl-leucine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
PEPSTATIN , A NEW PEPSIN INHIBITOR PRODUCED
  • 2006
  • Corpus ID: 27770074
Sir: A specific inhibitor of an enzyme might be useful for the analysis of certain pathogenic phenomena and also perhaps for the… 
1982
1982
Effects of various protease inhibitors on phagocytosis of antigen-antibody complex by macrophages.
In order to characterize proteases of macrophages involved in phagocytosis, the effects of various protease inhibitors were… 
1981
1981
Synthesis of leupeptins and inhibition of proteinases. I. Inhibition of acrosin and trypsin.
A series of leupeptin analogs R-L-leucyl-L-leucyl-L-argininal with variable N-terminal substituents has been synthesized using N… 
1980
1980
SUPPRESSION AND ACCELERATION OF EXPERIMENTAL AMYLOIDOSIS IN MOUSE MODEL
Leupeptins, protease inhibitors, suppress the appearance of experimental amyloidosis in CBA mice induced by the injections with… 
1975
1975
Studies on cathepsins of rat liver lysosomes. II. Comparative studies on multiple forms of cathepsin A.
The multiple forms of cathepsin A (AI, AII, and AIII) purified from the lysosome fraction of rat liver by Sephadex G-200 and DEAE… 
1972
1972
Proteases of macrophages in rat peritoneal exudate, with special reference to the effects of actinomycete protease inhibitors.
1972
1972
Synthetic studies on leupeptins and their analogs.
An imidazolide (4) obtained from carbobenzoxy-NG=-nitro-L-arginine (3) was reduced with lithium aluminum hydride to give… 
1971
1971
The structure and activity of leupeptins and related analogs.
leucyl-DL-argininal (leupeptin Ac-LL) and propionyl-L-leucyl-L-leucyl-DL-argininal (leupeptin Pr-LL), confirmed by chemical… 
Highly Cited
1969
Highly Cited
1969
Biological activities of leupeptins.
Leupeptins, leupeptin Pr and leupeptin Ac, strongly inhibit proteolysis by plasmin, trypsin and papain, but do not inhibit… 
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