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Leukocyte-Adhesion Deficiency Syndrome

Known as: Syndrome, Leukocyte-Adhesion Deficiency, Deficiency Syndrome, Leukocyte-Adhesion, Deficiency Syndrome, Leukocyte Adhesion 
Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18… 
National Institutes of Health

Related topics

Related topics

10 relations
CD18 AntigensIn BloodMicrobiologicalReceptors, Leukocyte-Adhesion

Narrower (2)

Leukocyte Adhesion Deficiency, Type IIILeukocyte adhesion deficiency type 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.
Recently, we reported a rare leukocyte adhesion deficiency (LAD) associated with severe defects in integrin activation by… 
Highly Cited
2000
Highly Cited
2000
Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes from a patient with leukocyte adhesion deficiency-1: normal displacement in close quarters via chimneying.
The beta2 integrins are known to be important in the motile function of leukocytes in general and in the adhesive response to… 
1999
1999
Continuous heparinization and circulating adhesion molecules in the critically ill.
Endothelial activation and damage are common endpoints of a complex process that may result in multiple organ dysfunction… 
1997
1997
Alteration in leukocyte adhesion molecule expression following minor, moderate and major trauma.
An understanding of the mechanisms of post-injury leukocyte trafficking is essential to the development of future therapeutic… 
Highly Cited
1995
Highly Cited
1995
Levels of soluble adhesion molecules and cytokines in patients with septic multiple organ failure.
Multiple organ failure (MOF) is a common complication of sepsis or septic shock. In this condition, it is believed that activated… 
1994
1994
Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.
It is well accepted that the induction of endothelial cell (EC) adhesion molecules is a critical component in acute inflammatory… 
1993
1993
Fetal Neutrophils and Eosinophils Express Normal Levels of L-Selectin
ABSTRACT: L-selectin is a leukocyte adhesion molecule important in the initial stages of the interaction of neutrophils with… 
Highly Cited
1992
Highly Cited
1992
Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins.
1992
1992
Distribution of lymphocytes and cell adhesion molecules in iris biopsy specimens from patients with uveitis.
To investigate the mechanisms responsible for lymphocyte accumulation in the eye in uveitis, we examined iris biopsy specimens… 
1991
1991
Adhesion molecules in the pathogenesis of asthma.
Using a primate antigen inhalation model the mechanisms involved in the induction of airway hyperresponsiveness were studied… 
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