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Leukocyte-Adhesion Deficiency Syndrome

Known as: Syndrome, Leukocyte-Adhesion Deficiency, Deficiency Syndrome, Leukocyte-Adhesion, Deficiency Syndrome, Leukocyte Adhesion 
Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18… 
National Institutes of Health

Related topics

Related topics

10 relations
CD18 AntigensIn BloodMicrobiologicalReceptors, Leukocyte-Adhesion

Narrower (2)

Leukocyte Adhesion Deficiency, Type IIILeukocyte adhesion deficiency type 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
The role of antibody synergy and membrane fluidity in the vascular targeting of immunoliposomes.
2008
2008
Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium
We have recently reported that the human lymphatic endothelium has toll-like receptor 4 (TLR4)-mediated lipopolysaccharide… 
Highly Cited
2004
Highly Cited
2004
LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.
Recently, we reported a rare leukocyte adhesion deficiency (LAD) associated with severe defects in integrin activation by… 
Highly Cited
2000
Highly Cited
2000
Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes from a patient with leukocyte adhesion deficiency-1: normal displacement in close quarters via chimneying.
The beta2 integrins are known to be important in the motile function of leukocytes in general and in the adhesive response to… 
Highly Cited
1995
Highly Cited
1995
Levels of soluble adhesion molecules and cytokines in patients with septic multiple organ failure.
Multiple organ failure (MOF) is a common complication of sepsis or septic shock. In this condition, it is believed that activated… 
Highly Cited
1995
Highly Cited
1995
Neutrophil sequestration and pulmonary dysfunction in a canine model of open heart surgery with cardiopulmonary bypass. Evidence for a CD18-dependent mechanism.
BACKGROUND Previous studies documented an inflammatory reaction to cardiopulmonary bypass with neutrophil (PMN) sequestration in… 
1994
1994
Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.
It is well accepted that the induction of endothelial cell (EC) adhesion molecules is a critical component in acute inflammatory… 
1994
1994
Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea‐pig skin
1 Intradermal injection of the complement fragment C5a des Arg induces local oedema formation that, in rabbits and man, is… 
1993
1993
Fetal Neutrophils and Eosinophils Express Normal Levels of L-Selectin
ABSTRACT: L-selectin is a leukocyte adhesion molecule important in the initial stages of the interaction of neutrophils with… 
1992
1992
Granulocyte accumulation in postischemic intestine: role of leukocyte adhesion glycoprotein CD11/CD18.
Neutrophils play an important role in ischemia-reperfusion (I/R)-induced vascular injury in the small intestine. Monoclonal… 
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