Leukocyte adhesion deficiency type 1

Known as: LAD1, Leukocyte Adhesion Deficiency, Type I, LAD-Type I 
A rare immunodeficiency with an autosomal recessive pattern of inheritance. It is caused by mutation in the ITGB2 gene on chromosome 21 which codes… (More)

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Topic mentions per year

1956-2017
010020030019562016

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Highly Cited
2009
Highly Cited
2009
Integrins are the major adhesion receptors of leukocytes and platelets. β1 and β2 integrin function on leukocytes is crucial for… (More)
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Highly Cited
2009
Highly Cited
2009
Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell–specific… (More)
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2007
2007
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive disorder caused by mutations in the ITGB2 (CD18) gene and… (More)
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Highly Cited
2007
Highly Cited
2007
Single gene mutations in beta integrins can account for functional defects of individual cells of the hematopoietic system. In… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Multislice spiral computed tomography (MSCT) is a promising technique for noninvasive coronary angiography, although… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Myocardial strain is a measure of regional deformation, and by definition, negative strain means shortening and… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVES This study was designed to evaluate whether calcium deposition in the coronary arteries is related to atherosclerotic… (More)
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Highly Cited
1997
Highly Cited
1997
Leukocyte adhesion deficiency (LAD) is characterized by the inability of leukocytes, in particular neutrophilic granulocytes, to… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Although the Thrombolysis in Myocardial Infarction (TIMI) flow grade is valuable and widely used qualitative measure… (More)
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Highly Cited
1987
Highly Cited
1987
Leukocyte adhesion deficiency (LAD) is a recently recognized autosomal-recessive trait characterized by recurrent bacterial… (More)
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