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Intracellular signalling controlling integrin activation in lymphocytes
  • T. Kinashi
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 July 2005
Recent studies have provided new insight into the pathways that control the regulation of integrin activity and the coordination of complex cellular functions, such as the homing of lymphocytes and the formation of an immunological synapse. Expand
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
Human RAPL stimulated lymphocyte polarization and the patch-like redistribution of lymphocyte-function-associated antigen 1 (LFA-1) to the leading edge, resulting in enhanced adhesion to intercellular adhesion molecule 1 (ICAM-1). Expand
Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs1
A comprehensive view of the stromal composition and architecture of SLOs is presented, finding that MRCs were commonly observed at particular sites in various SLOs even in Rag2−/− mice, but were not found in ectopic lymphoid tissues, suggesting that MECs are a developmentally determined element. Expand
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
It is demonstrated that Rap1 plays a pivotal role in chemokine-induced integrin activation and migration and induced a polarized morphology, accompanied by the redistribution of CXCR4 and CD44 to the leading edge and uropod, respectively. Expand
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
'Knockdown' of the gene encoding Mst1 demonstrated its requirement for the induction of both a polarized morphology and integrin LFA-1 clustering and adhesion triggered by chemokines and T cell receptor ligation. Expand
Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase
Distinct from H-Ras and Rac, Rap1 increased the adhesiveness independently of PI 3-kinase, indicating that Rap1 is a novel activation signal for the integrins. Expand
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
It is shown that the effector molecule RAPL is indispensable in the integrin-mediated adhesion and migration of lymphocytes and dendritic cells and is a crucial immune cell trafficking regulator essential for immunosurveillance. Expand
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
Results imply that interaction between Peptide-25/I-Ab and TCR may primarily influence determination of the fate of naive CD4+ T cells in their differentiation towards the Th1 subset. Expand
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
It is shown that DOCK8 is a Cdc42-specific guanine nucleotide exchange factor that is critical for interstitial DC migration, and that in the absence of Dock8, DCs failed to accumulate in the lymph node parenchyma for T-cell priming. Expand
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
It is shown that the Ste20‐like kinase Mst1 plays crucial roles in lymphocyte trafficking in vivo and is a key enzyme involved in lymphocytes entry and interstitial migration. Expand