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Lethal Dose 50

Known as: Dose 50, Lethal, Lethal Dose - 50%, LC-50 
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the… Expand
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

drug potency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Plant extracts for developing mosquito larvicides: From laboratory to the field, with insights on the modes of action.
In the last decades, major research efforts have been done to investigate the insecticidal activity of plant-based products… Expand
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Review
2018
Review
2018
Toxicological Effects of Berberine and Sanguinarine
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic… Expand
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Review
2018
Review
2018
Biological Activities and Safety of Citrus spp. Essential Oils
Citrus fruits have been a commercially important crop for thousands of years. In addition, Citrus essential oils are valuable in… Expand
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Review
2016
Review
2016
p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities.
p-Coumaric acid (4-hydroxycinnamic acid) is a phenolic acid that has low toxicity in mice (LD50 = 2850 mg kg(-1) body weight… Expand
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Highly Cited
2010
Highly Cited
2010
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
Gold nanoparticles have attracted enormous scientific and technological interest due to their ease of synthesis, chemical… Expand
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Highly Cited
2005
Highly Cited
2005
A new approach to practical acute toxicity testing
  • D. Lorke
  • Archives of Toxicology
  • 2005
    • Corpus ID: 39225667
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is… Expand
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Highly Cited
1986
Highly Cited
1986
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.
By limiting dilution of WEHI 164 mouse fibrosarcoma cells we have isolated a cell line, WEHI 164 clone 13, which is extremely… Expand
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Highly Cited
1985
Highly Cited
1985
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
A highly specific polyclonal rabbit antiserum directed against murine cachectin/tumor necrosis factor (TNF) was prepared. When… Expand
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Highly Cited
1984
Highly Cited
1984
Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent.
Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly… Expand
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Highly Cited
1952
Highly Cited
1952
Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use.
 
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