Lethal Dose 50

Known as: Dose 50, Lethal, Lethal Dose - 50%, LC-50 
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the… (More)
National Institutes of Health

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Broader (1)

drug potency

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Review
2017
Review
2017
The C. elegans model in toxicity testing
Caenorhabditis elegans is a small nematode that can be maintained at low cost and handled using standard in vitro techniques… (More)
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Highly Cited
2011
Highly Cited
2011
Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice.
Mesoporous hollow silica nanoparticles (MHSNs) are emerging as one of the new and promising nanomaterials for biomedical… (More)
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Highly Cited
2005
Highly Cited
2005
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms… (More)
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Review
2004
Review
2004
Biotic ligand model, a flexible tool for developing site-specific water quality guidelines for metals.
The biotic ligand model (BLM) is a mechanistic approach that greatly improves our ability to generate site-specific ambient water… (More)
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Highly Cited
2004
Highly Cited
2004
Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene.
Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved in cadmium-related toxicity… (More)
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Highly Cited
1995
Highly Cited
1995
In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides.
Reactive oxygen species may be involved in the toxicity of various pesticides and we have, therefore, examined the in vivo… (More)
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Highly Cited
1989
Highly Cited
1989
Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.
Invasion of the intestinal epithelium is thought to be an important step in the pathogenesis of Salmonella infections. Using an… (More)
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Highly Cited
1986
Highly Cited
1986
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.
By limiting dilution of WEHI 164 mouse fibrosarcoma cells we have isolated a cell line, WEHI 164 clone 13, which is extremely… (More)
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Highly Cited
1985
Highly Cited
1985
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
A highly specific polyclonal rabbit antiserum directed against murine cachectin/tumor necrosis factor (TNF) was prepared. When… (More)
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Highly Cited
1983
Highly Cited
1983
A new approach to practical acute toxicity testing
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is… (More)
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