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Lethal Dose 50

Known as: Dose 50, Lethal, Lethal Dose - 50%, LC-50 
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

drug potency

Papers overview

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Highly Cited
2000
Highly Cited
2000
Synthesis, structural characterization and antitumor activity of novel 2,4-diamino-1,3,5-triazine derivatives.
Highly Cited
1999
Highly Cited
1999
Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma.
OBJECTIVE To determine whether blood lactate, base deficit, or oxygen-derived hemodynamic variables correlate with morbidity and… 
Highly Cited
1987
Highly Cited
1987
Purification and some properties of Shiga-like toxin from Escherichia coli O157:H7 that is immunologically identical to Shiga toxin.
Highly Cited
1987
Highly Cited
1987
Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues.
In this report we describe various aspects of tumor and normal tissue radiosensitization by nicotinamide. The LD50 for a single… 
Highly Cited
1984
Highly Cited
1984
Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.
The effect of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity… 
Highly Cited
1984
Highly Cited
1984
Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman.
Highly Cited
1984
Highly Cited
1984
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).
Highly Cited
1980
Highly Cited
1980
STUDIES ON THE IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORIN A IN RATS RECEIVING RENAL ALLOGRAFTS
The immunosuppressive effects of cyclosporin A were tested in a DA (RT-1a) to Lewis (RT-11) rat renal allograft model, which… 
Highly Cited
1978
Highly Cited
1978
The effect of cadmium on the hematology and on the activity of delta-aminolevulinic acid dehydratase (ALA-D) in blood and hematopoietic tissues of the flounder, Pleuronectes flesus L.
Highly Cited
1976
Highly Cited
1976
Effect of hypnotics on mice genetically selected for sensitivity to ethanol
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