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Lethal Dose 50

Known as: Dose 50, Lethal, Lethal Dose - 50%, LC-50 
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

drug potency

Papers overview

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Highly Cited
1999
Highly Cited
1999
Molecular Medicine © 1999 The Picower Institute Press Infectivity of Scrapie Prions Bound to a Stainless
  • 1999
  • Corpus ID: 14726446
Highly Cited
1997
Highly Cited
1997
A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague.
Highly Cited
1987
Highly Cited
1987
Isolation and structural studies of the intact scrapie agent protein.
Highly Cited
1985
Highly Cited
1985
Cell cycle-dependent repair of double-strand DNA breaks in a γ-ray-sensitive Chinese hamster cell
A Chinese hamster cell mutant has been isolated which is extremely sensitive to killing by γ-irradiation in the G1, and early S… 
Highly Cited
1984
Highly Cited
1984
Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.
The effect of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity… 
Highly Cited
1984
Highly Cited
1984
Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman.
Highly Cited
1976
Highly Cited
1976
The nephrotoxic effects of cis-diammine-dichloroplatinum (II) (NSC-119875) in male F344 rats.
Highly Cited
1976
Highly Cited
1976
Effect of hypnotics on mice genetically selected for sensitivity to ethanol
Highly Cited
1973
Highly Cited
1973
General biological effects of TCDD in laboratory animals.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is reported to be one of the most toxic chemicals known. There has been variation in… 
Highly Cited
1967
Highly Cited
1967
The relationship of DNA content to nuclear and chromosome volumes and to radiosensitivity (LD50).
Factors which in the past have been invoked to explain the different responses of a wide range of organisms to ionizing radiation… 
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