Lethal Dose 50

Known as: Dose 50, Lethal, Lethal Dose - 50%, LC-50 
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Caenorhabditis elegans is a small nematode that can be maintained at low cost and handled using standard in vitro techniques… (More)
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Highly Cited
2011
Highly Cited
2011
Mesoporous hollow silica nanoparticles (MHSNs) are emerging as one of the new and promising nanomaterials for biomedical… (More)
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Highly Cited
2005
Highly Cited
2005
Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms… (More)
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Review
2004
Review
2004
The biotic ligand model (BLM) is a mechanistic approach that greatly improves our ability to generate site-specific ambient water… (More)
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Highly Cited
2004
Highly Cited
2004
Cadmium is a well-known human carcinogen and a potent nephrotoxin. Lipid peroxidation is involved in cadmium-related toxicity… (More)
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Highly Cited
1995
Highly Cited
1995
Reactive oxygen species may be involved in the toxicity of various pesticides and we have, therefore, examined the in vivo… (More)
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Highly Cited
1989
Highly Cited
1989
Invasion of the intestinal epithelium is thought to be an important step in the pathogenesis of Salmonella infections. Using an… (More)
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Highly Cited
1986
Highly Cited
1986
By limiting dilution of WEHI 164 mouse fibrosarcoma cells we have isolated a cell line, WEHI 164 clone 13, which is extremely… (More)
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Highly Cited
1985
Highly Cited
1985
A highly specific polyclonal rabbit antiserum directed against murine cachectin/tumor necrosis factor (TNF) was prepared. When… (More)
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Highly Cited
1983
Highly Cited
1983
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is… (More)
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