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Genome sequence of Yersinia pestis, the causative agent of plague
The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics:Expand
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Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the worldExpand
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The complete genome sequence of Francisella tularensis, the causative agent of tularemia
Francisella tularensis is one of the most infectious human pathogens known. In the past, both the former Soviet Union and the US had programs to develop weapons containing the bacterium. We reportExpand
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Tularaemia: bioterrorism defence renews interest in Francisella tularensis
Francisella tularensis is a highly infectious aerosolizable intracellular pathogen that is capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming units. There is noExpand
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Bacterial phospholipases C.
  • R. Titball
  • Biology, Medicine
  • Microbiological reviews
  • 1 June 1993
A variety of pathogenic bacteria produce phospholipases C, and since the discovery in 1944 that a bacterial toxin (Clostridium perfringens alpha-toxin) possessed an enzymatic activity, there has beenExpand
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SUMMARY Francisella tularensis is the etiological agent of tularemia, a serious and occasionally fatal disease of humans and animals. In humans, ulceroglandular tularemia is the most common form ofExpand
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Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible for a wideExpand
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Occurrence of Clostridium perfringens beta2-toxin amongst animals, determined using genotyping and subtyping PCR assays.
Clostridium perfringens isolates are currently classified into one of five biotypes on the basis of the differential production of alpha-, beta-, epsilon- and iota-toxins. Different biotypes areExpand
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Structure of the key toxin in gas gangrene
Clostridium perfringens α-toxin is the key virulence determinant in gas gangrene and has also been implicated in the pathogenesis of sudden death syndrome in young animals. The toxin is aExpand
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Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens.
For decades, low doses of antibiotics have been used widely in animal production to promote growth. However, there is a trend to reduce this use of antibiotics in feedstuffs, and legislation is nowExpand
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