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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
TLDR
It is demonstrated that FXR/BAR is critical for bile acid and lipid homeostasis by virtue of its role as an intracellular bile Acid sensor. Expand
Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
TLDR
Mice lacking hepatic HNF4α expression accumulated lipid in the liver and exhibited greatly reduced serum cholesterol and triglyceride levels and increased serum bile acid concentrations, indicating that this factor is central to the maintenance of hepatocyte differentiation and is a major in vivo regulator of genes involved in the control of lipid homeostasis. Expand
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
TLDR
In situ hybridization showed that the T/ebp gene is expressed in the normal thyroid, lung bronchial epithelium, and specific areas of the forebrain during early embryogenesis, establishing that the expression of T/EBP, a transcription factor known to control thyroid-specific gene transcription, is also essential for organogenesis of the thyroid, lungs, ventral forebrain, and pituitary. Expand
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
TLDR
The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton. Expand
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
TLDR
Pathological examination revealed an excessive inflammatory response with massive infiltration of lymphocytes and macrophages in many organs, but primarily in heart and lungs, which suggests a prominent role for TGF-beta 1 in homeostatic regulation of immune cell proliferation and extravasation into tissues. Expand
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
TLDR
Cdk5(-/-) mice exhibit unique lesions in the central nervous system associated with perinatal mortality and also suggest that Cdk5 may play critical roles in neuronal cytoskeleton structure and organization. Expand
Pathology of mouse models of intestinal cancer: consensus report and recommendations.
TLDR
This paper presents a poster presented at the 2015 American Academy of Pathology Congress, entitled “Advances in Pathology and Laboratory Medicine: Foundations of Precision Pathology, 2nd Ed.” in Cleveland, Ohio. Expand
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
TLDR
It is shown that Meis1‐deficient embryos have partially duplicated retinas and smaller lenses than normal and may also be required for the proliferation/self‐renewal of the HSC. Expand
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.
TLDR
A mouse model was generated through homologous recombination of the mouse homolog Men1 to examine the role of MEN1 in tumor formation, supporting its role as a tumor suppressor gene. Expand
Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology
TLDR
It is recommended that investigators use the Bar Harbor Classification system when characterizing new GEM models or when conducting experimental interventions that may alter the phenotype or natural history of lesion progression in existing models. Expand
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