Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
- G. Hayhurst, Ying‐Hue Lee, G. Lambert, J. Ward, F. Gonzalez
- Biology, MedicineMolecular and Cellular Biology
- 15 February 2001
Mice lacking hepatic HNF4α expression accumulated lipid in the liver and exhibited greatly reduced serum cholesterol and triglyceride levels and increased serum bile acid concentrations, indicating that this factor is central to the maintenance of hepatocyte differentiation and is a major in vivo regulator of genes involved in the control of lipid homeostasis.
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
In situ hybridization showed that the T/ebp gene is expressed in the normal thyroid, lung bronchial epithelium, and specific areas of the forebrain during early embryogenesis, establishing that the expression of T/EBP, a transcription factor known to control thyroid-specific gene transcription, is also essential for organogenesis of the thyroid, lungs, ventral forebrain, and pituitary.
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
- A. Kulkarni, C. Huh, S. Karlsson
- Biology, MedicineProceedings of the National Academy of Sciences…
- 15 January 1993
Pathological examination revealed an excessive inflammatory response with massive infiltration of lymphocytes and macrophages in many organs, but primarily in heart and lungs, which suggests a prominent role for TGF-beta 1 in homeostatic regulation of immune cell proliferation and extravasation into tissues.
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
- T. Ohshima, J. Ward, A. Kulkarni
- BiologyProceedings of the National Academy of Sciences…
- 1 October 1996
Cdk5(-/-) mice exhibit unique lesions in the central nervous system associated with perinatal mortality and also suggest that Cdk5 may play critical roles in neuronal cytoskeleton structure and organization.
Pathology of mouse models of intestinal cancer: consensus report and recommendations.
This paper presents a poster presented at the 2015 American Academy of Pathology Congress, entitled “Advances in Pathology and Laboratory Medicine: Foundations of Precision Pathology, 2nd Ed.” in Cleveland, Ohio.
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.
Treatment of immunodeficient mice bearing human breast carcinoma cells with a neutralizing antibody to MCP-1 resulted in significant increases in survival and inhibition of the growth of lung micrometastases, indicating that M CP-1 can act as a direct mediator of angiogenesis.
Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology…
It is recommended that investigators use the Bar Harbor Classification system when characterizing new GEM models or when conducting experimental interventions that may alter the phenotype or natural history of lesion progression in existing models.