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Sox2, which encodes an SRY-like HMG box transcription factor, is critical for vertebrate development. Sox2 mediates its… Expand Pax6 is a pivotal regulator of eye development throughout Metazoa, but the direct upstream regulators of vertebrate Pax6… Expand The Pax6 transcription factor plays a key role in ocular development of vertebrates and invertebrates. Homozygosity of the Pax6… Expand In the mouse mutant dysgenetic lens (dyl) the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens… Expand The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that… Expand Targeted inactivation of the Bmp7 gene in mouse leads to eye defects with late onset and variable penetrance (A. T. Dudley et al… Expand After the vertebrate lens is induced from head ectoderm, lens-specific genes are expressed. Transcriptional regulation of the… Expand Development of the eye can be subdivided into three phases. The first phase is the formation of the major structures of the eye… Expand Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities. We have examined the… Expand The Pax-6 gene encodes a DNA-binding transcription factor essential to normal development of the mammalian eye. We have found… Expand