Bernd Fritzsch

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Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.

Chenghua Gu, Ezequiel Rodríguez, +5 authors David D Ginty
Developmental cell
2003

Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated… (More)

Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit.

Veronica Matei, Stefanie Pauley, +7 authors Bernd Fritzsch
Developmental dynamics : an official publication…
2005

We investigated whether co-expression of Neurog 1 and Atoh 1 in common neurosensory precursors could explain the loss of hair cells in Neurog 1 null mice. Analysis of terminal mitosis, using BrdU,… (More)

Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear.

Alar Karis, Illar Pata, +4 authors Bernd Fritzsch
The Journal of comparative neurology
2001

Patterning the vertebrate ear requires the coordinated expression of genes that are involved in morphogenesis, neurogenesis, and hair cell formation. The zinc finger gene GATA-3 is expressed both in… (More)

Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression.

Isabel Fariñas, Kevin R. Jones, +8 authors Bernd Fritzsch
The Journal of neuroscience : the official…
2001

Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear innervation patterning in different null mutants. We now show that all NT-3 null mutants have a similar… (More)

NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development.

William Y. Kim, Bernd Fritzsch, +5 authors Jacqueline E. Lee
Development
2001

A key factor in the genetically programmed development of the nervous system is the death of massive numbers of neurons. Therefore, genetic mechanisms governing cell survival are of fundamental… (More)

Auditory system development: primary auditory neurons and their targets.

Edwin W. Rubel, Bernd Fritzsch
Annual review of neuroscience
2002

The neurons of the cochlear ganglion transmit acoustic information between the inner ear and the brain. These placodally derived neurons must produce a topographically precise pattern of connections… (More)

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.

Alain Dabdoub, Chandrakala Puligilla, +4 authors Matthew William Kelley
Proceedings of the National Academy of Sciences…
2008

Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing loss and a loss… (More)

Proprioceptor Pathway Development Is Dependent on MATH1

Nessan A. Bermingham, Bassem A Hassan, +5 authors Huda Y. Zoghbi
Neuron
2001

The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic… (More)

Neurogenin 1 Null Mutant Ears Develop Fewer, Morphologically Normal Hair Cells in Smaller Sensory Epithelia Devoid of Innervation

Qiufu Ma, David J. Anderson, Bernd Fritzsch
Journal of the Association for Research in…
2000

The proneuronal gene neurogenin 1 (ngn1) is essential for development of the inner-ear sensory neurons that are completely absent in ngn1 null mutants. Neither afferent, efferent, nor autonomic nerve… (More)

Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution

Jeramiah J Smith, Shigehiro Kuraku, +56 authors Weiming Li
Nature Genetics
2013

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is… (More)

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