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Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
TLDR
It is proposed that the absence of NEUROG1 protein leads to loss of sensory neuron formation through a phenotypic switch of cycling neurosensory precursors from sensory neuron to hair cell fate.
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
TLDR
It is demonstrated that decreased levels of Sox2 result in precocious hair cell differentiation and an over production of inner hair cells and that these effects are likely mediated through an antagonistic interaction between Sox2 and the bHLH molecule Atoh1.
Transcription factor GATA‐3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
TLDR
This study shows for the first time that a zinc finger factor is involved in axonal navigation of the inner ear efferent neurons and, simultaneously, in the morphogenesis of the outer ear.
FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis
TLDR
Genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear is provided, suggesting that in contrast to mesenchymal–epithelial-based FGF10 signaling demonstrated for other organs, the innerEar seems to depend on paracrine signals that operate within the epithelium.
Expression and function of FGF10 in mammalian inner ear development
TLDR
In situ hybridization data reveal expression of FGF10 in all three canal crista sensory epithelia and the cochlea anlage as well as all sensory neurons at embryonic day 11.5, and most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of F GF10's main receptors.
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain.
TLDR
Results indicate the existence of a molecular hierarchy in which FGF8 signalling establishes the graded expression of En-2 within the tectum, and may act to specify other aspects of A-P polarity such as graded ELF-1 expression.
Auditory system development: primary auditory neurons and their targets.
TLDR
Current evidence suggests that while ganglion cells have little influence on the differentiation of their hair cell targets, quite the opposite is true in the brain.
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
TLDR
Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages, and help define key evolutionary events within vertebrate lineages.
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