Leigh Disease

Known as: LEIGH SYNDROME, Subacute Necrotizing Encephalomyelopathies, Subacute Necrotizing Encephalomyelopathy 
A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration… (More)
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Highly Cited
2008
Highly Cited
2008
We present a new technique called “t-SNE” that visualizes high-dimensional data by giving each datapoint a location in a two or… (More)
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Review
2008
Review
2008
Leigh syndrome (also termed subacute, necrotizing encephalopathy) is a devastating neurodegenerative disorder, characterized by… (More)
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Highly Cited
2003
Highly Cited
2003
Although the parietal cortex has been implicated in the neural processes underlying visual attention, the nature of its… (More)
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Highly Cited
2002
Highly Cited
2002
Devic's disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating disease of the CNS, characterized by… (More)
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Highly Cited
1998
Highly Cited
1998
Leigh disease associated with cytochrome c oxidase deficiency (LD[COX-]) is one of the most common disorders of the mitochondrial… (More)
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Highly Cited
1998
Highly Cited
1998
Leigh Syndrome (LS) is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical… (More)
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Highly Cited
1996
Highly Cited
1996
We investigated the etiology of Leigh syndrome in 67 Australian cases from 56 pedigrees, 35 with a firm diagnosis and 32 with… (More)
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Highly Cited
1992
Highly Cited
1992
A female infant showing lacticacidemia, hypotonia, and neurodegenerative disease died at 7 mo of age. Autopsy revealed lesions… (More)
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Highly Cited
1987
Highly Cited
1987
We studied 6 mitochondrial enzymes in crude extracts and isolated mitochondria from 5 children with pathologically proven… (More)
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