FAQ

Acidosis, Lactic

Known as: ACIDOSIS LACTIC, lactacidosis, Lactic acidosis 
Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases… (More)

Topic mentions per year

Topic mentions per year

1943-2018
010020019432017

Related topics

Related topics

46 relations
3-METHYLGLUTACONIC ACIDURIA WITH DEAFNESS, ENCEPHALOPATHY, AND LEIGH-LIKE SYNDROMEAcid-Base EquilibriumCOMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 12COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19
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Broader (2)

AcidemiaNutritional and Metabolic Diseases

Narrower (3)

Combined Oxidative Phosphorylation Deficiency 4GRACILE SYNDROME (disorder)Pyruvate Dehydrogenase E1 Alpha Deficiency

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Acidosis, Lactic
radiotherapeutic
prevention & control
Microbiological
nursing therapy
chemically induced

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are… (More)
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Highly Cited
2006
Highly Cited
2006
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
OBJECTIVE Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital… (More)
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2003
2003
Lactic acidosis
Lactate is a byproduct of glycolysis. In the energyproducing metabolism of glucose two distinct processes occur. The first series… (More)
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Highly Cited
2000
Highly Cited
2000
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here… (More)
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Highly Cited
1996
Highly Cited
1996
Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD.
Early lactic acidosis during exercise and abnormal skeletal muscle function have been reported in chronic obstructive pulmonary… (More)
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Highly Cited
1995
Highly Cited
1995
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.
BACKGROUND We describe severe and unexpected multisystem toxicity that occurred during a study of the antiviral nucleoside… (More)
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Highly Cited
1992
Highly Cited
1992
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group.
BACKGROUND Mortality is very high in lactic acidosis, and there is no satisfactory treatment other than treatment of the… (More)
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Highly Cited
1990
Highly Cited
1990
Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study.
STUDY OBJECTIVE To determine whether correction of acidemia using bicarbonate improves hemodynamics in patients who have lactic… (More)
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Highly Cited
1984
Highly Cited
1984
Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome.
We report on two patients who have a mitochondrial myopathy, encephalopathy, lactic acidosis, and recurrent cerebral insults that… (More)
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Highly Cited
1981
Highly Cited
1981
Brain lactic acidosis and ischemic cell damage: 2. Histopathology.
The influence of severe tissue lactic acidosis during incomplete brain ischemia (30 min) on cortex morphology was studied in… (More)
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