Lactulose

Known as: 4-O-beta-D-Galactopyranosyl-D-fructose, 4-O-beta-D-Galactopyranosyl-D-fructofuranose, Lactulosum 
A disaccharide (sugar) synthesized from fructose and galactose, Lactulose is used to treat constipation and some liver diseases. Nondigestible in… (More)
National Institutes of Health

Related topics

Related topics

29 relations
Acidifying Activity [MoA]ConstipationDrug AllergyGalactosemias
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Narrower (7)

AmivalexDuphalacEnuloseFZ 560
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Broader (2)

DisaccharidesGastrointestinal Agents

Papers overview

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Highly Cited
2009
Highly Cited
2009
Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo.
BACKGROUND & AIMS Hepatic encephalopathy (HE) is associated with a poor prognosis. Lactulose is used for the treatment of HE… (More)
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Highly Cited
2007
Highly Cited
2007
Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy.
UNLABELLED Minimal hepatic encephalopathy (MHE) has a negative effect on patients' daily functioning. Thus far, no study has… (More)
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Highly Cited
2003
Highly Cited
2003
Normalization of Lactulose Breath Testing Correlates With Symptom Improvement in Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Study
OBJECTIVE:We have recently found an association between abnormal lactulose breath test (LBT) findings and irritable bowel… (More)
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Highly Cited
2003
Highly Cited
2003
Methane Production During Lactulose Breath Test Is Associated with Gastrointestinal Disease Presentation
It has recently been determined that there is an increased prevalence of bacterial overgrowth in IBS. Since there are two gases… (More)
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Highly Cited
2000
Highly Cited
2000
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome.
BACKGROUND AND AIMS Post-dysenteric irritable bowel syndrome (PD-IBS) develops in up to 25% of patients following Campylobacter… (More)
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Highly Cited
1999
Highly Cited
1999
Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation.
BACKGROUND Polyethylene glycol (PEG) 3350 is a non-absorbable, non-metabolised osmotic agent used in lavage solutions for gut… (More)
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Highly Cited
1996
Highly Cited
1996
The lactulose breath hydrogen test and small intestinal bacterial overgrowth.
OBJECTIVES To i) document the sensitivity and specificity of a combined scintigraphic/lactulose breath hydrogen test for small… (More)
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Highly Cited
1985
Highly Cited
1985
Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study).
The effects of a chronic load of nonabsorbable sugars on intracolonic bacterial metabolism of carbohydrates and on H2 breath… (More)
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Highly Cited
1980
Highly Cited
1980
The hepatic coma syndromes and lactulose
auteurs is beschreven (BOURNERIAS e.a. 1978; STIMESSE e.a. 1978 en COHEN e.a. 1979). Een andere verklaring voor het optreden van… (More)
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Highly Cited
1977
Highly Cited
1977
Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial.
A randomized double blind clinical comparison of neomycin and lactulose was performed in 33 cirrhotic patients with chronic… (More)
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