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A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung.
TLDR
Adjuvant chemotherapy with uracil-tegafur improves survival among patients with completely resected pathological stage I adenocarcinoma of the lung.
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The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.
TLDR
The role of the HLA class I allele in unrelated bone marrow transplantation was elucidated, and Notably, HLA-C alleles had a different mode from Hla-A or -B alleles for acute GVHD and survival.
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Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease
TLDR
In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis.
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Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population
TLDR
In a Japanese population, another risk variant in ABCG2, namely the Q126X nonfunctional mutation, confers an even higher risk associated with an increase in uric acid deposition in the blood and may cause gout in Asians, lending weight to previously reported GWAS.
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Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis.
TLDR
P53 alteration was a significant marker of poor prognosis in patients with pulmonary adenocarcinoma and whether p53 alteration also provides information that can alter treatment decisions should be asked in clinical trials.
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A Large‐scale, Hospital‐based Case‐Control Study of Risk Factors of Breast Cancer According to Menopausal Status
TLDR
Large‐scale, hospital‐based case‐control study to evaluate differences and similarities in the risk factors of female breast cancer according to menopausal status found a protective effect of physical activity against breast cancer was observed among both pre‐ and post‐menopausal women.
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NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese
TLDR
This study suggests that the CC genotype of the NQO1 C609T polymorphism is associated with the risk of lung cancer, and that the TT genotype increases therisk of smoking for cancers of the esophagus and lung.
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Healthcare waste management in the capital city of Mongolia.
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Foods and beverages in relation to urothelial cancer: Case‐control study in Japan
TLDR
The role of several foods and beverages in the development of bladder cancer remain unclear and the need for further research into these mechanisms is still unclear.
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Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver.
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