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LYN protein, human

Known as: LYN, p53-LYN, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, human 
Tyrosine-protein kinase Lyn (512 aa, ~59 kDa) is encoded by the human LYN gene. This protein plays a role in tyrosine phosphorylation, signal… 
National Institutes of Health

Related topics

Related topics

21 relations
B Cell Receptor Signaling PathwayCell Differentiation processCell ProliferationEnzyme Gene

Broader (1)

lyn protein-tyrosine kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.
Although the Abelson (Abl) tyrosine kinase inhibitor imatinib mesylate has improved the treatment of breakpoint cluster region… 
Highly Cited
2004
Highly Cited
2004
Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase
A role for Lyn kinase as a positive regulator of immunoglobulin (Ig)E-dependent allergy has long been accepted. Contrary to this… 
Highly Cited
2002
Highly Cited
2002
BANK regulates BCR‐induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor
B‐cell activation mediated through the antigen receptor is dependent on activation of protein tyrosine kinases (PTKs) such as Lyn… 
Highly Cited
1998
Highly Cited
1998
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
Protein tyrosine phosphorylation plays a crucial role in signaling from the receptor for erythropoietin (Epo), although the Epo… 
Highly Cited
1998
Highly Cited
1998
Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
Highly Cited
1997
Highly Cited
1997
Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains*
The earliest known step in the activation of the high affinity IgE receptor, FcεRI, is the tyrosine phosphorylation of its β and… 
Highly Cited
1994
Highly Cited
1994
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
Highly Cited
1994
Highly Cited
1994
Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.
Highly Cited
1992
Highly Cited
1992
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases
THE high-affinity IgE receptor (FcɛRI), which is expressed on the surface of mast cells and basophils, has a central role in… 
Highly Cited
1992
Highly Cited
1992
Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.
Crosslinking of membrane-bound immunoglobulins, which are B-cell antigen receptors, causes proliferation and differentiation of B… 
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