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LY 294002

Known as: LY-294002, LY294002 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS.
Highly Cited
2002
Highly Cited
2002
Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation*
The protein serine-threonine kinase Akt mediates cell survival signaling initiated by various growth-promoting factors such as… 
Highly Cited
2001
Highly Cited
2001
Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons
The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the… 
Highly Cited
2001
Highly Cited
2001
Insulin Regulates Alternative Splicing of Protein Kinase C βII through a Phosphatidylinositol 3-Kinase-dependent Pathway Involving the Nuclear Serine/Arginine-rich Splicing Factor, SRp40, in Skeletal…
Insulin regulates the inclusion of the exon encoding protein kinase C (PKC) βII mRNA. In this report, we show that insulin… 
Highly Cited
2001
Highly Cited
2001
Trypanosoma cruzi trans-sialidase: A potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling
Patients infected with Trypanosoma cruzi may remain asymptomatic for decades and show signs of neuroregeneration in the… 
Highly Cited
2001
Highly Cited
2001
The Phosphoinositide-dependent Kinase, PDK-1, Phosphorylates Conventional Protein Kinase C Isozymes by a Mechanism That Is Independent of Phosphoinositide 3-Kinase*
Phosphorylation by the phosphoinositide-dependent kinase, PDK-1, is required for the activation of diverse members of the AGC… 
Highly Cited
1999
Highly Cited
1999
The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase
ABSTRACT Stimulation of the hepatocyte growth factor (HGF) receptor tyrosine kinase, Met, induces mitogenesis, motility, invasion… 
Highly Cited
1998
Highly Cited
1998
Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal.
Insulin-like growth factor-I (IGF-I) is emerging as an important growth factor able to modulate the programmed cell death (PCD… 
Highly Cited
1997
Highly Cited
1997
Signaling Pathways through Which Insulin Regulates CCAAT/Enhancer Binding Protein α (C/EBPα) Phosphorylation and Gene Expression in 3T3-L1 Adipocytes
Treatment of 3T3-L1 adipocytes with insulin (IC50 ∼200 pm insulin) or insulin-like growth factor-1 (IC50 ∼200 pm IGF-1… 
Highly Cited
1989
Highly Cited
1989
A new methodology for the optimal design and production schedule of multipurpose batch plants
Presentation d'une procedure algorithmique determinant simultanement le programme optimal de production et les tailles des… 
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