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LY 274614

Known as: 3-Isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3alpha,4aalpha,6beta,8aalpha)-, LY-274614, LY274614 
National Institutes of Health

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Related topics

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Broader (1)

Isoquinolines

Papers overview

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Highly Cited
1995
Highly Cited
1995
Characterization of the Excitotoxic Potential of the Reversible Succinate Dehydrogenase Inhibitor Malonate
Abstract: Although the mechanism of neuronal death in neurodegenerative diseases remains unknown, it has been hypothesized that… 
Review
1995
Review
1995
The Role of the Locus Coeruleus and N-Methyl-D-Aspartic Acid (NMDA) and AMPA Receptors in Opiate Withdrawal
Review
1995
Review
1995
N-Methyl-D-Aspartate (NMDA) Receptors, Mu and Kappa Opioid Tolerance, and Perspectives on New Analgesic Drug Development
Highly Cited
1995
Highly Cited
1995
Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.
Highly Cited
1994
Highly Cited
1994
The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-l-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids
Highly Cited
1994
Highly Cited
1994
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.
Recent reports have demonstrated that the coadministration of morphine with an N-methyl-D-aspartate (NMDA) receptor antagonist… 
Highly Cited
1993
Highly Cited
1993
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
The ability of a competitive (LY274614; (+-)-6-phosphonomethyl-decahydroisoquinolin-3-carboxylic acid) and a noncompetitive… 
Highly Cited
1993
Highly Cited
1993
NMDA antagonists partially protect against MPTP induced neurotoxicity in mice
RECENT studies show that Af-methyl-D-aspartate (NMDA) antagonists protect against neurotoxicity induced by local injections of 1… 
Highly Cited
1991
Highly Cited
1991
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
Highly Cited
1991
Highly Cited
1991
In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor Effects
Abstract: This study explored further the function of the metabotropic excitatory amino acid receptor in the rat brain. The trans… 
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