FAQ

LRRK2 wt Allele

Known as: RIPK7, Leucine-Rich Repeat Kinase 2 wt Allele, DARDARIN 
Human LRRK2 wild-type allele is located in the vicinity of 12q12 and is approximately 144 kb in length. This allele, which encodes leucine-rich… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
02420042018

Related topics

Related topics

9 relations
12q12Homo sapiensLRRK2 geneLeucine-Rich Repeat Serine/Threonine-Protein Kinase 2
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Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
LRRK2 wt Allele
Parkinson Disease
Signal Transduction
Homo sapiens
LRRK2 gene
Phosphorylation

Papers overview

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2012
2012
LRRK2 I2020T mutation is associated with tau pathology.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal-dominant familial Parkinson's… (More)
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2012
2012
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene have been identified in PARK8, a major form of autosomal-dominantly… (More)
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2009
2009
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain… (More)
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2009
2009
Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
BACKGROUND Since the causative gene linked to PARK8 parkinsonism was identified as LRRK2, LRRK2 gene mutations have been found to… (More)
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Highly Cited
2007
Highly Cited
2007
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Leucine-rich repeat kinase 2 (LRRK2), a product of a causative gene for the autosomal-dominant form of familial Parkinson's… (More)
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Highly Cited
2006
Highly Cited
2006
Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
OBJECTIVE The PARK8 gene responsible for late-onset autosomal dominant Parkinson's disease encodes a large novel protein of… (More)
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2006
2006
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from… (More)
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Highly Cited
2005
Highly Cited
2005
Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.
Hertie Institute of Clinical Brain Research, Department of Medical Genetics and Department of Neuroradiology, University of T… (More)
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Highly Cited
2005
Highly Cited
2005
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.
BACKGROUND Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked… (More)
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Highly Cited
2004
Highly Cited
2004
The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.
Recently, a new locus (PARK8) for autosomal dominant parkinsonism has been identified in one large Japanese family. Linkage has… (More)
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