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LRRK2 wt Allele

Known as: RIPK7, Leucine-Rich Repeat Kinase 2 wt Allele, DARDARIN 
Human LRRK2 wild-type allele is located in the vicinity of 12q12 and is approximately 144 kb in length. This allele, which encodes leucine-rich… Expand
National Institutes of Health

Related topics

Related topics

9 relations
12q12Homo sapiensLRRK2 geneLeucine-Rich Repeat Serine/Threonine-Protein Kinase 2
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
LRRK2 I2020T mutation is associated with tau pathology.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal-dominant familial Parkinson's… Expand
2012
2012
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene have been identified in PARK8, a major form of autosomal-dominantly… Expand
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Highly Cited
2010
Highly Cited
2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus
Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain… Expand
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2008
2008
Genetic and environmental findings in early‐onset Parkinson's disease Brazilian patients
Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors. In this study, we investigated… Expand
Highly Cited
2006
Highly Cited
2006
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from… Expand
Highly Cited
2005
Highly Cited
2005
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucine-rich repeat kinase 2 (LRRK2… Expand
Highly Cited
2005
Highly Cited
2005
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
We detected a missense mutation in the kinase domain of the LRRK2 gene in members with autosomal dominant Parkinson's disease of… Expand
Highly Cited
2005
Highly Cited
2005
Familial Parkinson's disease: Clinical and genetic analysis of four Basque families
During the last few years several loci have been linked to Mendelian forms of Parkinson's disease (PD). To date, 5 causative… Expand
Highly Cited
2004
Highly Cited
2004
Autosomal dominant parkinsonism associated with variable synuclein and tau pathology
Since the original 1995 report of a parkinsonian kindred, four individuals have been affected (mean age at onset, 65 years). All… Expand
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