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LRRK2 wt Allele

Known as: RIPK7, Leucine-Rich Repeat Kinase 2 wt Allele, DARDARIN 
Human LRRK2 wild-type allele is located in the vicinity of 12q12 and is approximately 144 kb in length. This allele, which encodes leucine-rich… Expand
National Institutes of Health

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9 relations
12q12Homo sapiensLRRK2 geneLeucine-Rich Repeat Serine/Threonine-Protein Kinase 2
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Papers overview

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2012
2012
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene have been identified in PARK8, a major form of autosomal-dominantly… Expand
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2012
2012
LRRK2 I2020T mutation is associated with tau pathology.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal-dominant familial Parkinson's… Expand
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2011
2011
Non-5q spinal muscular atrophies: the alphanumeric soup thickens.
Spinal muscular atrophies (SMAs) are hereditary disorders characterized by degeneration of motor neurons in the spinal cord and… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain… Expand
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2008
2008
Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients.
Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors. In this study, we investigated… Expand
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Highly Cited
2006
Highly Cited
2006
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from… Expand
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Highly Cited
2005
Highly Cited
2005
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucine-rich repeat kinase 2 (LRRK2… Expand
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Highly Cited
2005
Highly Cited
2005
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.
We detected a missense mutation in the kinase domain of the LRRK2 gene in members with autosomal dominant Parkinson's disease of… Expand
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2005
2005
Familial Parkinson's disease: clinical and genetic analysis of four Basque families.
During the last few years several loci have been linked to Mendelian forms of Parkinson's disease (PD). To date, 5 causative… Expand
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Highly Cited
2004
Highly Cited
2004
Autosomal dominant parkinsonism associated with variable synuclein and tau pathology
Since the original 1995 report of a parkinsonian kindred, four individuals have been affected (mean age at onset, 65 years). All… Expand
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