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LRRK2 wt Allele
Known as:
RIPK7
, Leucine-Rich Repeat Kinase 2 wt Allele
, DARDARIN
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Human LRRK2 wild-type allele is located in the vicinity of 12q12 and is approximately 144 kb in length. This allele, which encodes leucine-rich…
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National Institutes of Health
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Related topics
Related topics
9 relations
12q12
Homo sapiens
LRRK2 gene
Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Identification of osimertinib resistance mechanisms in Chinese NSCLC patients: Analysis from AURA17 trial.
Min Hu
,
Yi-long Wu
,
+15 authors
Caicun Zhou
2018
Corpus ID: 80801100
9077Background: Osimertinib is approved for metastatic NSCLC patients with EGFR T790M mutation after progression from EGFR-TKI…
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Review
2017
Review
2017
1353PCNS response to osimertinib in Asian-Pacific patients (pts) with T790M-positive advanced NSCLC: data from an open-label Phase II trial (AURA17)
C. Zhou
,
Y. Cheng
,
+7 authors
Y. Wu
2017
Corpus ID: 80075542
trials(AURAextension:NCT01802632,AURA2:NCT02094261)inptswithT790M-positiveadvancedNSCLC…
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2013
2013
The common PARK8 mutation LRRK2G2019S is not a risk factor for breast cancer in the absence of Parkinson’s disease
H. Mortiboys
,
A. Cox
,
I. Brock
,
O. Bandmann
Journal of Neurology
2013
Corpus ID: 9396632
Parkinson’s Disease (PD) results from excessive neuronal cell death, most predominantly dopaminergic neurons in the substantia…
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2013
2013
Aktuelles zu den genetischen Ursachen der Parkinson-Krankheit: Implikationen für die molekulare Pathogenese und Diagnostik
C. Mielke
,
K. Krüger
2013
Corpus ID: 82111824
Update on the Genetics of Parkinson’s Disease: Implications for Molecular Pathogenesis and Diagnosis. Besides the more frequent…
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2011
2011
Up with the lark
L. Silveira-Moriyama
,
A. Lees
Neurology
2011
Corpus ID: 13327481
In 2004, the gene for the leucine-rich repeat kinase 2 (LRRK2) was cloned simultaneously by 2 groups. Zimprich et al.1 described…
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2010
2010
PARK 16 as a susceptibility locus Analysis of GWAS-linked loci in Parkinson disease reaffirms
E. Tan
,
H. Kwok
,
+9 authors
T. Toda
2010
Corpus ID: 207785854
2009
2009
CliniCal and moleCular neuroimaging CharaCteristiCs of Brazilian patients with parkinson ’ s disease and mutations in PARK 2 or PARK 8 genes
O. Barsottini
,
A. Felício
,
+6 authors
L. Andrade
2009
Corpus ID: 4673053
Objective: To describe clinical and neuroimaging (SPECT) characteristics of Brazilian patients with Parkinson’s disease (PD) and…
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2007
2007
Parkin polymorphisms and environmental exposure: decrease in age at onset of Parkinson's disease.
Isabella Ghione
,
A. Di Fonzo
,
+4 authors
M. Rango
Neurotoxicology
2007
Corpus ID: 22917072
2007
2007
Discovery and characterization of LRRK2, gene responsible for PARK8-linked Parkinson disease
S. Jain
2007
Corpus ID: 89241753
Parkinson disease (PD) is an incurable movement disorder clinically characterized by resting tremor, bradykinesia and other…
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Highly Cited
2005
Highly Cited
2005
Familial Parkinson's disease: Clinical and genetic analysis of four Basque families
C. Paisán-Ruiz
,
A. Sáenz
,
+4 authors
J. Pérez-Tur
Annals of Neurology
2005
Corpus ID: 21063961
During the last few years several loci have been linked to Mendelian forms of Parkinson's disease (PD). To date, 5 causative…
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