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LRRK2 wt Allele
Known as:
RIPK7
, Leucine-Rich Repeat Kinase 2 wt Allele
, DARDARIN
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Human LRRK2 wild-type allele is located in the vicinity of 12q12 and is approximately 144 kb in length. This allele, which encodes leucine-rich…
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National Institutes of Health
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Related topics
Related topics
9 relations
12q12
Homo sapiens
LRRK2 gene
Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
LRRK2 I2020T mutation is associated with tau pathology.
Sachiko Ujiie
,
T. Hatano
,
+8 authors
N. Hattori
Parkinsonism & related disorders
2012
Corpus ID: 29435900
Highly Cited
2010
Highly Cited
2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus
E. Tan
,
H. Kwok
,
+9 authors
J.-J. Liu
Neurology
2010
Corpus ID: 33337197
Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD…
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Review
2010
Review
2010
Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
W. Seol
BMB reports
2010
Corpus ID: 25955345
Parkinson's disease (PD) is the second most common neurodegenerative disease, and 5-10% of the PD cases are genetically inherited…
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Highly Cited
2009
Highly Cited
2009
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Rosa M. Sancho
,
B. Law
,
K. Harvey
Human molecular genetics
2009
Corpus ID: 12643402
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain…
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2008
2008
Genetic and environmental findings in early‐onset Parkinson's disease Brazilian patients
P. de Carvalho Aguiar
,
P. Lessa
,
+8 authors
L. Andrade
Movement disorders : official journal of the…
2008
Corpus ID: 32472092
Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors. In this study, we investigated…
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Highly Cited
2006
Highly Cited
2006
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
N. Nakamura
,
Y. Shimaoka
,
+14 authors
T. Ochi
DNA research : an international journal for rapid…
2006
Corpus ID: 19361103
We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from…
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Highly Cited
2005
Highly Cited
2005
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
J. Kachergus
,
I. Mata
,
+15 authors
M. Toft
American journal of human genetics
2005
Corpus ID: 23289000
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucine-rich repeat kinase 2 (LRRK2…
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Highly Cited
2005
Highly Cited
2005
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
M. Funayama
,
K. Hasegawa
,
+5 authors
F. Obata
Annals of neurology
2005
Corpus ID: 38756929
We detected a missense mutation in the kinase domain of the LRRK2 gene in members with autosomal dominant Parkinson's disease of…
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Highly Cited
2005
Highly Cited
2005
Familial Parkinson's disease: Clinical and genetic analysis of four Basque families
C. Paisán-Ruiz
,
A. Sáenz
,
+4 authors
J. Pérez-Tur
Annals of neurology
2005
Corpus ID: 21063961
During the last few years several loci have been linked to Mendelian forms of Parkinson's disease (PD). To date, 5 causative…
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Highly Cited
2004
Highly Cited
2004
Autosomal dominant parkinsonism associated with variable synuclein and tau pathology
Z. Wszolek
,
R. Pfeiffer
,
+10 authors
D. Dickson
Neurology
2004
Corpus ID: 44782231
Since the original 1995 report of a parkinsonian kindred, four individuals have been affected (mean age at onset, 65 years). All…
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